DOCK5 (dedicator of cytokinesis 5)

2014-08-01  

Identity

HGNC
LOCATION
8p21.2
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 80005
MIM: 616904
HGNC: 23476
Ensembl: ENSG00000147459

Variants:

dbSNP: 80005
ClinVar: 80005
TCGA: ENSG00000147459
COSMIC: DOCK5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000147459ENST00000276440Q9H7D0
ENSG00000147459ENST00000410074B9A015
ENSG00000147459ENST00000444569H0Y7N4
ENSG00000147459ENST00000467709H0YB14
ENSG00000147459ENST00000481100Q9H7D0

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
HemostasisREACTOMER-HSA-109582
Factors involved in megakaryocyte development and platelet productionREACTOMER-HSA-983231

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
225959692012Novel association approach for variable number tandem repeats (VNTRs) identifies DOCK5 as a susceptibility gene for severe obesity.9
190048292009DOCK5 and DOCK1 regulate Caco-2 intestinal epithelial cell spreading and migration on collagen IV.8
299459952018Characterization of Alternative Splicing Events in HPV-Negative Head and Neck Squamous Cell Carcinoma Identifies an Oncogenic DOCK5 Variant.8
276694372017The focal adhesion-associated proteins DOCK5 and GIT2 comprise a rheostat in control of epithelial invasion.6
290895022017Allosteric inhibition of the guanine nucleotide exchange factor DOCK5 by a small molecule.4

Citation

Dessen P

DOCK5 (dedicator of cytokinesis 5)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54260/dock5-(dedicator-of-cytokinesis-5)