DOCK5 (dedicator of cytokinesis 5)

2014-08-01  

Identity

HGNC
DOCK5
LOCATION
8p21.2
LOCUSID
80005
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 80005
MIM: 616904
HGNC: 23476
Ensembl: ENSG00000147459

Variants:

dbSNP: 80005
ClinVar: 80005
TCGA: ENSG00000147459
COSMIC: DOCK5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000147459ENST00000276440Q9H7D0
ENSG00000147459ENST00000410074B9A015
ENSG00000147459ENST00000444569H0Y7N4
ENSG00000147459ENST00000467709H0YB14
ENSG00000147459ENST00000481100Q9H7D0

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
HemostasisREACTOMER-HSA-109582
Factors involved in megakaryocyte development and platelet productionREACTOMER-HSA-983231

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
381612292024Dock5 Deficiency Promotes Proteinuric Kidney Diseases via Modulating Podocyte Lipid Metabolism.1
381612292024Dock5 Deficiency Promotes Proteinuric Kidney Diseases via Modulating Podocyte Lipid Metabolism.1
374342352023PHF5A regulates the expression of the DOCK5 variant to promote HNSCC progression through p38 MAPK activation.2
374342352023PHF5A regulates the expression of the DOCK5 variant to promote HNSCC progression through p38 MAPK activation.2
329205992021Positional cloning and comprehensive mutation analysis of a Japanese family with lithium-responsive bipolar disorder identifies a novel DOCK5 mutation.3
342166862021ZEB1 represses biogenesis of circ-DOCK5 to facilitate metastasis in esophageal squamous cell carcinoma via a positive feedback loop with TGF-β.19
329205992021Positional cloning and comprehensive mutation analysis of a Japanese family with lithium-responsive bipolar disorder identifies a novel DOCK5 mutation.3
342166862021ZEB1 represses biogenesis of circ-DOCK5 to facilitate metastasis in esophageal squamous cell carcinoma via a positive feedback loop with TGF-β.19
299459952018Characterization of Alternative Splicing Events in HPV-Negative Head and Neck Squamous Cell Carcinoma Identifies an Oncogenic DOCK5 Variant.21
299459952018Characterization of Alternative Splicing Events in HPV-Negative Head and Neck Squamous Cell Carcinoma Identifies an Oncogenic DOCK5 Variant.21
276694372017The focal adhesion-associated proteins DOCK5 and GIT2 comprise a rheostat in control of epithelial invasion.19
290895022017Allosteric inhibition of the guanine nucleotide exchange factor DOCK5 by a small molecule.13
276694372017The focal adhesion-associated proteins DOCK5 and GIT2 comprise a rheostat in control of epithelial invasion.19
290895022017Allosteric inhibition of the guanine nucleotide exchange factor DOCK5 by a small molecule.13
225959692012Novel association approach for variable number tandem repeats (VNTRs) identifies DOCK5 as a susceptibility gene for severe obesity.13

Citation

Dessen P

DOCK5 (dedicator of cytokinesis 5)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54260/dock5-(dedicator-of-cytokinesis-5)