DRD4 (dopamine receptor D4)

2014-08-01  

Identity

HGNC
LOCATION
11p15.5
LOCUSID
ALIAS
D4DR
FUSION GENES

Other Information

Locus ID:

NCBI: 1815
MIM: 126452
HGNC: 3025
Ensembl: ENSG00000069696

Variants:

dbSNP: 1815
ClinVar: 1815
TCGA: ENSG00000069696
COSMIC: DRD4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000069696ENST00000176183P21917

Expression (GTEx)

0
1
2
3
4
5
6
7
8

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Dopaminergic synapseKEGGko04728
Dopaminergic synapseKEGGhsa04728
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Amine ligand-binding receptorsREACTOMER-HSA-375280
Dopamine receptorsREACTOMER-HSA-390651
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

References

Pubmed IDYearTitleCitations
185839792008Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database.395
195069062009Candidate gene studies of ADHD: a meta-analytic review.263
178937062009Genetic variation in components of dopamine neurotransmission impacts ventral striatal reactivity associated with impulsivity.157
168943952006The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes.153
168943952006The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes.153
167749752006Meta-analysis shows significant association between dopamine system genes and attention deficit hyperactivity disorder (ADHD).139
201164372010Reward circuitry responsivity to food predicts future increases in body mass: moderating effects of DRD2 and DRD4.122
201164372010Reward circuitry responsivity to food predicts future increases in body mass: moderating effects of DRD2 and DRD4.122
114312262001Meta-analysis of the association between the 7-repeat allele of the dopamine D(4) receptor gene and attention deficit hyperactivity disorder.118
181940282008Experimental evidence for differential susceptibility: dopamine D4 receptor polymorphism (DRD4 VNTR) moderates intervention effects on toddlers' externalizing behavior in a randomized controlled trial.106

Citation

Dessen P

DRD4 (dopamine receptor D4)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54266/drd4-(dopamine-receptor-d4)