EIF3D (eukaryotic translation initiation factor 3 subunit D)

2014-08-01  

Identity

HGNC
LOCATION
22q12.3
LOCUSID
ALIAS
EIF3S7,eIF3-p66,eIF3-zeta
FUSION GENES

Other Information

Locus ID:

NCBI: 8664
MIM: 603915
HGNC: 3278
Ensembl: ENSG00000100353

Variants:

dbSNP: 8664
ClinVar: 8664
TCGA: ENSG00000100353
COSMIC: EIF3D

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100353ENST00000216190O15371
ENSG00000100353ENST00000402116B0QYA8
ENSG00000100353ENST00000405442O15371
ENSG00000100353ENST00000455547B0QYA5
ENSG00000100353ENST00000457241B0QYA6
ENSG00000100353ENST00000458572B0QYA4
ENSG00000100353ENST00000478547A0A0D9SGB5

Expression (GTEx)

0
50
100
150
200
250
300
350

Pathways

PathwaySourceExternal ID
RNA transportKEGGko03013
RNA transportKEGGhsa03013
Metabolism of proteinsREACTOMER-HSA-392499
TranslationREACTOMER-HSA-72766
Eukaryotic Translation InitiationREACTOMER-HSA-72613
Cap-dependent Translation InitiationREACTOMER-HSA-72737
Formation of a pool of free 40S subunitsREACTOMER-HSA-72689
Formation of the ternary complex, and subsequently, the 43S complexREACTOMER-HSA-72695
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43SREACTOMER-HSA-72662
Translation initiation complex formationREACTOMER-HSA-72649
Ribosomal scanning and start codon recognitionREACTOMER-HSA-72702
GTP hydrolysis and joining of the 60S ribosomal subunitREACTOMER-HSA-72706
L13a-mediated translational silencing of Ceruloplasmin expressionREACTOMER-HSA-156827
Gene ExpressionREACTOMER-HSA-74160

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
362646102023EIF3D promoted cervical carcinoma through Warburg effect by interacting with GRP78.2
369970882023eIF3d: A driver of noncanonical cap-dependent translation of specific mRNAs and a trigger of biological/pathological processes.5
371444682023Translational fidelity screens in mammalian cells reveal eIF3 and eIF4G2 as regulators of start codon selectivity.5
373149292023Breast cancer cell mesenchymal transition and metastasis directed by DAP5/eIF3d-mediated selective mRNA translation.10
376836482023eIF3d controls the persistent integrated stress response.7
362646102023EIF3D promoted cervical carcinoma through Warburg effect by interacting with GRP78.2
369970882023eIF3d: A driver of noncanonical cap-dependent translation of specific mRNAs and a trigger of biological/pathological processes.5
371444682023Translational fidelity screens in mammalian cells reveal eIF3 and eIF4G2 as regulators of start codon selectivity.5
373149292023Breast cancer cell mesenchymal transition and metastasis directed by DAP5/eIF3d-mediated selective mRNA translation.10
376836482023eIF3d controls the persistent integrated stress response.7
351041702022Overexpression of Eukaryotic translation initiation factor 3D induces stem cell-like properties and metastasis in cervix cancer by activating FAK through inhibiting degradation of GRP78.5
351041702022Overexpression of Eukaryotic translation initiation factor 3D induces stem cell-like properties and metastasis in cervix cancer by activating FAK through inhibiting degradation of GRP78.5
345207902021EIF3D promotes the progression of preeclampsia by inhibiting of MAPK/ERK1/2 pathway.3
348486852021A DAP5/eIF3d alternate mRNA translation mechanism promotes differentiation and immune suppression by human regulatory T cells.21
345207902021EIF3D promotes the progression of preeclampsia by inhibiting of MAPK/ERK1/2 pathway.3

Citation

Dessen P

EIF3D (eukaryotic translation initiation factor 3 subunit D)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54279/eif3d-(eukaryotic-translation-initiation-factor-3-subunit-d)