Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 55140
MIM: 612722
HGNC: 20696
Ensembl: ENSG00000134014
Variants:
dbSNP: 55140
ClinVar: 55140
TCGA: ENSG00000134014
COSMIC: ELP3
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Chromatin organization | REACTOME | R-HSA-4839726 |
| Chromatin modifying enzymes | REACTOME | R-HSA-3247509 |
| HATs acetylate histones | REACTOME | R-HSA-3214847 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37640114 | 2024 | Amyloid pathology reduces ELP3 expression and tRNA modifications leading to impaired proteostasis. | 1 |
| 37640114 | 2024 | Amyloid pathology reduces ELP3 expression and tRNA modifications leading to impaired proteostasis. | 1 |
| 35722999 | 2022 | Relation between the circular and linear form of the Elongator Acetyltransferase Complex Subunit 3 in the progression of triple-negative breast cancer. | 1 |
| 35722999 | 2022 | Relation between the circular and linear form of the Elongator Acetyltransferase Complex Subunit 3 in the progression of triple-negative breast cancer. | 1 |
| 31341009 | 2019 | ELP3 Acetyltransferase is phosphorylated and regulated by the oncogenic anaplastic lymphoma kinase (ALK). | 4 |
| 31341009 | 2019 | ELP3 Acetyltransferase is phosphorylated and regulated by the oncogenic anaplastic lymphoma kinase (ALK). | 4 |
| 29805303 | 2018 | Elongator promotes the migration and invasion of hepatocellular carcinoma cell by the phosphorylation of AKT. | 8 |
| 29805303 | 2018 | Elongator promotes the migration and invasion of hepatocellular carcinoma cell by the phosphorylation of AKT. | 8 |
| 27811057 | 2016 | Elp3 links tRNA modification to IRES-dependent translation of LEF1 to sustain metastasis in breast cancer. | 86 |
| 27811057 | 2016 | Elp3 links tRNA modification to IRES-dependent translation of LEF1 to sustain metastasis in breast cancer. | 86 |
| 24769394 | 2014 | Regulation of G6PD acetylation by SIRT2 and KAT9 modulates NADPH homeostasis and cell survival during oxidative stress. | 130 |
| 25148870 | 2014 | Promoter hypermethylation may be an important mechanism of the transcriptional inactivation of ARRDC3, GATA5, and ELP3 in invasive ductal breast carcinoma. | 15 |
| 24769394 | 2014 | Regulation of G6PD acetylation by SIRT2 and KAT9 modulates NADPH homeostasis and cell survival during oxidative stress. | 130 |
| 25148870 | 2014 | Promoter hypermethylation may be an important mechanism of the transcriptional inactivation of ARRDC3, GATA5, and ELP3 in invasive ductal breast carcinoma. | 15 |
| 20877300 | 2012 | Genome-wide association study of increasing suicidal ideation during antidepressant treatment in the GENDEP project. | 42 |
Citation
Dessen P
ELP3 (elongator acetyltransferase complex subunit 3)
Atlas Genet Cytogenet Oncol Haematol. 2014-08-01
Online version: http://atlasgeneticsoncology.org/gene/54282/deep-insight-explorer/
