Identity
HGNC
LOCATION
13q22.3
LOCUSID
ALIAS
FBL3,FBL3A,FBXL3A,IDDSFAS
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 26224
MIM: 605653
HGNC: 13599
Ensembl: ENSG00000005812
Variants:
dbSNP: 26224
ClinVar: 26224
TCGA: ENSG00000005812
COSMIC: FBXL3
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000005812 | ENST00000355619 | Q9UKT7 |
| ENSG00000005812 | ENST00000417323 | C9J0Y7 |
Expression (GTEx)
Pathways
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 30481285 | 2019 | Biallelic variants in FBXL3 cause intellectual disability, delayed motor development and short stature. | 8 |
| 30594330 | 2019 | FBXL3 is regulated by miRNA-4735-3p and suppresses cell proliferation and migration in non-small cell lung cancer. | 8 |
| 30481285 | 2019 | Biallelic variants in FBXL3 cause intellectual disability, delayed motor development and short stature. | 8 |
| 30594330 | 2019 | FBXL3 is regulated by miRNA-4735-3p and suppresses cell proliferation and migration in non-small cell lung cancer. | 8 |
| 28749470 | 2017 | miR-181d and c-myc-mediated inhibition of CRY2 and FBXL3 reprograms metabolism in colorectal cancer. | 36 |
| 28749470 | 2017 | miR-181d and c-myc-mediated inhibition of CRY2 and FBXL3 reprograms metabolism in colorectal cancer. | 36 |
| 27529127 | 2016 | A Cryptochrome 2 mutation yields advanced sleep phase in humans. | 58 |
| 27840026 | 2016 | CRY2 and FBXL3 Cooperatively Degrade c-MYC. | 96 |
| 27529127 | 2016 | A Cryptochrome 2 mutation yields advanced sleep phase in humans. | 58 |
| 27840026 | 2016 | CRY2 and FBXL3 Cooperatively Degrade c-MYC. | 96 |
| 26243628 | 2015 | Highly Efficient Genome Editing via CRISPR/Cas9 to Create Clock Gene Knockout Cells. | 11 |
| 26243628 | 2015 | Highly Efficient Genome Editing via CRISPR/Cas9 to Create Clock Gene Knockout Cells. | 11 |
| 23503662 | 2013 | SCF(FBXL3) ubiquitin ligase targets cryptochromes at their cofactor pocket. | 124 |
| 23616524 | 2013 | Distinct and separable roles for endogenous CRY1 and CRY2 within the circadian molecular clockwork of the suprachiasmatic nucleus, as revealed by the Fbxl3(Afh) mutation. | 36 |
| 24085301 | 2013 | Substrate binding promotes formation of the Skp1-Cul1-Fbxl3 (SCF(Fbxl3)) protein complex. | 19 |
Citation
Dessen P
FBXL3 (F-box and leucine rich repeat protein 3)
Atlas Genet Cytogenet Oncol Haematol. 2014-08-01
Online version: http://atlasgeneticsoncology.org/gene/54314/fbxl3-(f-box-and-leucine-rich-repeat-protein-3)
