GIGYF2 (GRB10 interacting GYF protein 2)

2014-08-01  

Identity

HGNC
GIGYF2
LOCATION
2q37.1
LOCUSID
26058
ALIAS
GYF2,PARK11,PERQ2,PERQ3,TNRC15
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 26058
MIM: 612003
HGNC: 11960
Ensembl: ENSG00000204120

Variants:

dbSNP: 26058
ClinVar: 26058
TCGA: ENSG00000204120
COSMIC: GIGYF2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000204120ENST00000373563Q6Y7W6
ENSG00000204120ENST00000409196Q6Y7W6
ENSG00000204120ENST00000409451Q6Y7W6
ENSG00000204120ENST00000409480I1E4Y6
ENSG00000204120ENST00000409547Q6Y7W6
ENSG00000204120ENST00000410033B8ZZD2
ENSG00000204120ENST00000421433C9JPV7
ENSG00000204120ENST00000421778C9JH78
ENSG00000204120ENST00000423659C9JHW1
ENSG00000204120ENST00000424038F8WCD5
ENSG00000204120ENST00000424414C9JZC0
ENSG00000204120ENST00000425040C9JXQ0
ENSG00000204120ENST00000426102C9JH18
ENSG00000204120ENST00000427233C9JC65
ENSG00000204120ENST00000427649C9J7G1
ENSG00000204120ENST00000428883C9JRZ2
ENSG00000204120ENST00000429187C9J0V6
ENSG00000204120ENST00000430720C9JHT0
ENSG00000204120ENST00000436349C9J1A6
ENSG00000204120ENST00000440945E7ESB6
ENSG00000204120ENST00000445650C9IYH5
ENSG00000204120ENST00000455139A0A1U8QZH8
ENSG00000204120ENST00000456491C9JW88
ENSG00000204120ENST00000458528F8WBF1
ENSG00000204120ENST00000629305I1E4Y6

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
332391982021Association study of DNAJC13, UCHL1, HTRA2, GIGYF2, and EIF4G1 with Parkinson's disease.11
346658232021Translational repression of NMD targets by GIGYF2 and EIF4E2.17
332391982021Association study of DNAJC13, UCHL1, HTRA2, GIGYF2, and EIF4G1 with Parkinson's disease.11
346658232021Translational repression of NMD targets by GIGYF2 and EIF4E2.17
327265782020GIGYF2 and 4EHP Inhibit Translation Initiation of Defective Messenger RNAs to Assist Ribosome-Associated Quality Control.81
3305335520204EHP and GIGYF1/2 Mediate Translation-Coupled Messenger RNA Decay.27
327265782020GIGYF2 and 4EHP Inhibit Translation Initiation of Defective Messenger RNAs to Assist Ribosome-Associated Quality Control.81
3305335520204EHP and GIGYF1/2 Mediate Translation-Coupled Messenger RNA Decay.27
2955431020184EHP-independent repression of endogenous mRNAs by the RNA-binding protein GIGYF2.26
2955431020184EHP-independent repression of endogenous mRNAs by the RNA-binding protein GIGYF2.26
288734622017Genetic analysis of indel markers in three loci associated with Parkinson's disease.7
288734622017Genetic analysis of indel markers in three loci associated with Parkinson's disease.7
271571372016Post-transcriptional gene silencing activity of human GIGYF2.13
271571372016Post-transcriptional gene silencing activity of human GIGYF2.13
261345142015GIGYF2 mutation in late-onset Parkinson's disease with cognitive impairment.9

Citation

Dessen P

GIGYF2 (GRB10 interacting GYF protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54331