GORASP2 (golgi reassembly stacking protein 2)

2014-08-01  

Identity

HGNC
LOCATION
2q31.1
LOCUSID
ALIAS
GOLPH6,GRASP55,GRS2,p59
FUSION GENES

Other Information

Locus ID:

NCBI: 26003
MIM: 608693
HGNC: 17500
Ensembl: ENSG00000115806

Variants:

dbSNP: 26003
ClinVar: 26003
TCGA: ENSG00000115806
COSMIC: GORASP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115806ENST00000234160Q9H8Y8
ENSG00000115806ENST00000442798F8WF79
ENSG00000115806ENST00000444801F8WEG2
ENSG00000115806ENST00000454751F8WBR9
ENSG00000115806ENST00000455067F8WEH9

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic ProphaseREACTOMER-HSA-68875
Golgi Cisternae Pericentriolar Stack ReorganizationREACTOMER-HSA-162658

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
117394012001A GRASP55-rab2 effector complex linking Golgi structure to membrane traffic.84
118156312002Caspase-mediated cleavage of the stacking protein GRASP65 is required for Golgi fragmentation during apoptosis.74
200836032010GRASP55 and GRASP65 play complementary and essential roles in Golgi cisternal stacking.72
184345982008GRASP55 regulates Golgi ribbon formation.67
235520742013Regulation of protein glycosylation and sorting by the Golgi matrix proteins GRASP55/65.56
198409342009GRASP65 and GRASP55 sequentially promote the transport of C-terminal valine-bearing cargos to and through the Golgi complex.23
242278842014Isoform-specific tethering links the Golgi ribbon to maintain compartmentalization.20
288145012017Knockout of the Golgi stacking proteins GRASP55 and GRASP65 impairs Golgi structure and function.18
257017852015CD83 and GRASP55 interact in human dendritic cells.8
206089752010Golgi reassembly stacking protein 55 interacts with membrane-type (MT) 1-matrix metalloprotease (MMP) and furin and plays a role in the activation of the MT1-MMP zymogen.7

Citation

Dessen P

GORASP2 (golgi reassembly stacking protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54338/gorasp2-(golgi-reassembly-stacking-protein-2)