GOSR1 (golgi SNAP receptor complex member 1)

2014-08-01  

Identity

HGNC
LOCATION
17q11.2
LOCUSID
ALIAS
GOLIM2,GOS-28,GOS28,GOS28/P28,GS28,P28
FUSION GENES

Other Information

Locus ID:

NCBI: 9527
MIM: 604026
HGNC: 4430
Ensembl: ENSG00000108587

Variants:

dbSNP: 9527
ClinVar: 9527
TCGA: ENSG00000108587
COSMIC: GOSR1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000108587ENST00000225724O95249
ENSG00000108587ENST00000414833G5E9T8
ENSG00000108587ENST00000427274B4DQA8
ENSG00000108587ENST00000451249E9PCW1
ENSG00000108587ENST00000467337O95249
ENSG00000108587ENST00000537788F6RU00
ENSG00000108587ENST00000581721K7EJC8

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
SNARE interactions in vesicular transportKEGGko04130
SNARE interactions in vesicular transportKEGGhsa04130
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Transport to the Golgi and subsequent modificationREACTOMER-HSA-948021
ER to Golgi Anterograde TransportREACTOMER-HSA-199977
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
COPI-mediated anterograde transportREACTOMER-HSA-6807878
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Intra-Golgi trafficREACTOMER-HSA-6811438

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
123887522002GS15 forms a SNARE complex with syntaxin 5, GS28, and Ykt6 and is implicated in traffic in the early cisternae of the Golgi apparatus.50
165716792006RINT-1 regulates the localization and entry of ZW10 to the syntaxin 18 complex.34
223974102012Golgi-SNARE GS28 potentiates cisplatin-induced apoptosis by forming GS28-MDM2-p53 complexes and by preventing the ubiquitination and degradation of p53.8
233873392013Segregation of the Qb-SNAREs GS27 and GS28 into Golgi vesicles regulates intra-Golgi transport.6
216691982011OSBP-related protein 7 interacts with GATE-16 and negatively regulates GS28 protein stability.2
276110862016Nuclear Expression of GS28 Protein: A Novel Biomarker that Predicts Worse Prognosis in Cervical Cancers.2
207007302010Microarray analysis of differentially expressed genes in vaginal tissues in postmenopausal women. The role of stress urinary incontinence.0
286382662017Nuclear Expression of GS28 Protein: A Novel Biomarker that Predicts Prognosis in Colorectal Cancers.0

Citation

Dessen P

GOSR1 (golgi SNAP receptor complex member 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54339/gosr1-(golgi-snap-receptor-complex-member-1)