GPX6 (glutathione peroxidase 6)

2014-08-01  

Identity

HGNC
GPX6
LOCATION
6p22.1
LOCUSID
257202
ALIAS
GPX5p,GPXP3,GPx-6,GSHPx-6,dJ1186N24,dJ1186N24.1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 257202
MIM: 607913
HGNC: 4558
Ensembl: ENSG00000198704

Variants:

dbSNP: 257202
ClinVar: 257202
TCGA: ENSG00000198704
COSMIC: GPX6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198704ENST00000361902P59796
ENSG00000198704ENST00000474923A0A182DWH6
ENSG00000198704ENST00000612264A0A087X0K3

Expression (GTEx)

0
1
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Glutathione metabolismKEGGko00480
Arachidonic acid metabolismKEGGko00590
Glutathione metabolismKEGGhsa00480
Arachidonic acid metabolismKEGGhsa00590
Thyroid hormone synthesisKEGGhsa04918
Thyroid hormone synthesisKEGGko04918
Cellular responses to stressREACTOMER-HSA-2262752
Detoxification of Reactive Oxygen SpeciesREACTOMER-HSA-3299685

References

Pubmed IDYearTitleCitations
346888182022Association between genetic variants in oxidative stress-related genes and osteoporotic bone fracture. The Hortega follow-up study.3
346888182022Association between genetic variants in oxidative stress-related genes and osteoporotic bone fracture. The Hortega follow-up study.3
202004262010Glutathione pathway genetic polymorphisms and lung cancer survival after platinum-based chemotherapy.25
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.15
202004262010Glutathione pathway genetic polymorphisms and lung cancer survival after platinum-based chemotherapy.25
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.15
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.105
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.105

Citation

Dessen P

GPX6 (glutathione peroxidase 6)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54346/gene-explorer/teaching-explorer/