GULP1 (GULP PTB domain containing engulfment adaptor 1)

2014-08-01  

Identity

HGNC
GULP1
LOCATION
2q32.1
LOCUSID
51454
ALIAS
CED-6,CED6,GULP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51454
MIM: 608165
HGNC: 18649
Ensembl: ENSG00000144366

Variants:

dbSNP: 51454
ClinVar: 51454
TCGA: ENSG00000144366
COSMIC: GULP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000144366ENST00000359135Q9UBP9
ENSG00000144366ENST00000409580Q9UBP9
ENSG00000144366ENST00000409609Q9UBP9
ENSG00000144366ENST00000409637Q9UBP9
ENSG00000144366ENST00000409805Q9UBP9
ENSG00000144366ENST00000409830Q9UBP9
ENSG00000144366ENST00000409843Q9UBP9
ENSG00000144366ENST00000409927B8ZZL1
ENSG00000144366ENST00000410051Q9UBP9
ENSG00000144366ENST00000433052H7BZV7
ENSG00000144366ENST00000451191H0Y6R1

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
328173722020GULP1 regulates the NRF2-KEAP1 signaling axis in urothelial carcinoma.10
328173722020GULP1 regulates the NRF2-KEAP1 signaling axis in urothelial carcinoma.10
313738442019Attenuation of amyloid-β generation by atypical protein kinase C-mediated phosphorylation of engulfment adaptor PTB domain containing 1 threonine 35.0
314096532019Gulp1 controls Eph/ephrin trogocytosis and is important for cell rearrangements during development.7
315163092019Genomic/proteomic analyses of dexamethasone-treated human trabecular meshwork cells reveal a role for GULP1 and ABR in phagocytosis.17
313738442019Attenuation of amyloid-β generation by atypical protein kinase C-mediated phosphorylation of engulfment adaptor PTB domain containing 1 threonine 35.0
314096532019Gulp1 controls Eph/ephrin trogocytosis and is important for cell rearrangements during development.7
315163092019Genomic/proteomic analyses of dexamethasone-treated human trabecular meshwork cells reveal a role for GULP1 and ABR in phagocytosis.17
299642052018Integrated transcriptomic and epigenomic analysis of ovarian cancer reveals epigenetically silenced GULP1.10
299642052018Integrated transcriptomic and epigenomic analysis of ovarian cancer reveals epigenetically silenced GULP1.10
282843252017Expression of GULP1 in bronchial epithelium is associated with the progression of emphysema in chronic obstructive pulmonary disease.2
282843252017Expression of GULP1 in bronchial epithelium is associated with the progression of emphysema in chronic obstructive pulmonary disease.2
231672552013Engulfment adaptor phosphotyrosine-binding-domain-containing 1 (GULP1) is a nucleocytoplasmic shuttling protein and is transactivationally active together with low-density lipoprotein receptor-related protein 1 (LRP1).2
231672552013Engulfment adaptor phosphotyrosine-binding-domain-containing 1 (GULP1) is a nucleocytoplasmic shuttling protein and is transactivationally active together with low-density lipoprotein receptor-related protein 1 (LRP1).2
206740962012Engulfment adapter PTB domain containing 1 interacts with and affects processing of the amyloid-β precursor protein.6

Citation

Dessen P

GULP1 (GULP PTB domain containing engulfment adaptor 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54350/gulp1-(gulp-ptb-domain-containing-engulfment-adaptor-1)