HEXIM2 (HEXIM P-TEFb complex subunit 2)

2014-08-01  

Identity

HGNC
HEXIM2
LOCATION
17q21.31
LOCUSID
124790
ALIAS
L3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 124790
MIM: 615695
HGNC: 28591
Ensembl: ENSG00000168517

Variants:

dbSNP: 124790
ClinVar: 124790
TCGA: ENSG00000168517
COSMIC: HEXIM2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000168517ENST00000307275Q96MH2
ENSG00000168517ENST00000585340K7ERG7
ENSG00000168517ENST00000586681K7EJA3
ENSG00000168517ENST00000589230K7ELS4
ENSG00000168517ENST00000591070K7EIM4
ENSG00000168517ENST00000591576Q96MH2
ENSG00000168517ENST00000592695Q96MH2
ENSG00000168517ENST00000593138K7ESM2

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
198836592010Specificity of Hexim1 and Hexim2 complex formation with cyclin T1/T2, importin alpha and 7SK snRNA.15
198836592010Specificity of Hexim1 and Hexim2 complex formation with cyclin T1/T2, importin alpha and 7SK snRNA.15
157136612005Compensatory contributions of HEXIM1 and HEXIM2 in maintaining the balance of active and inactive positive transcription elongation factor b complexes for control of transcription.61
157136622005HEXIM2, a HEXIM1-related protein, regulates positive transcription elongation factor b through association with 7SK.66
159652332005Analysis of the large inactive P-TEFb complex indicates that it contains one 7SK molecule, a dimer of HEXIM1 or HEXIM2, and two P-TEFb molecules containing Cdk9 phosphorylated at threonine 186.127
157136612005Compensatory contributions of HEXIM1 and HEXIM2 in maintaining the balance of active and inactive positive transcription elongation factor b complexes for control of transcription.61
157136622005HEXIM2, a HEXIM1-related protein, regulates positive transcription elongation factor b through association with 7SK.66
159652332005Analysis of the large inactive P-TEFb complex indicates that it contains one 7SK molecule, a dimer of HEXIM1 or HEXIM2, and two P-TEFb molecules containing Cdk9 phosphorylated at threonine 186.127

Citation

Dessen P

HEXIM2 (HEXIM P-TEFb complex subunit 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54358/hexim2-(hexim-p-tefb-complex-subunit-2)