Identity
HGNC
LOCATION
12q13.13
LOCUSID
ALIAS
HOX3,HOX3E,cp19
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 3221
MIM: 142974
HGNC: 5126
Ensembl: ENSG00000198353
Variants:
dbSNP: 3221
ClinVar: 3221
TCGA: ENSG00000198353
COSMIC: HOXC4
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000198353 | ENST00000303406 | P09017 |
| ENSG00000198353 | ENST00000303406 | A0A024RB51 |
| ENSG00000198353 | ENST00000430889 | P09017 |
| ENSG00000198353 | ENST00000430889 | A0A024RB51 |
Expression (GTEx)
Pathways
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36433874 | 2023 | A likely HOXC4 predisposition variant for Chiari malformations. | 1 |
| 36433874 | 2023 | A likely HOXC4 predisposition variant for Chiari malformations. | 1 |
| 32977722 | 2021 | Homeobox C4 promotes hepatocellular carcinoma progression by the transactivation of Snail. | 5 |
| 32977722 | 2021 | Homeobox C4 promotes hepatocellular carcinoma progression by the transactivation of Snail. | 5 |
| 31913701 | 2020 | Suppression of long noncoding RNA MALAT1 inhibits the development of uveal melanoma via microRNA-608-mediated inhibition of HOXC4. | 17 |
| 31913701 | 2020 | Suppression of long noncoding RNA MALAT1 inhibits the development of uveal melanoma via microRNA-608-mediated inhibition of HOXC4. | 17 |
| 22298821 | 2012 | HOXC4 homeoprotein efficiently expands human hematopoietic stem cells and triggers similar molecular alterations as HOXB4. | 12 |
| 22298821 | 2012 | HOXC4 homeoprotein efficiently expands human hematopoietic stem cells and triggers similar molecular alterations as HOXB4. | 12 |
| 20855884 | 2010 | Estrogen receptors bind to and activate the HOXC4/HoxC4 promoter to potentiate HoxC4-mediated activation-induced cytosine deaminase induction, immunoglobulin class switch DNA recombination, and somatic hypermutation. | 49 |
| 20855884 | 2010 | Estrogen receptors bind to and activate the HOXC4/HoxC4 promoter to potentiate HoxC4-mediated activation-induced cytosine deaminase induction, immunoglobulin class switch DNA recombination, and somatic hypermutation. | 49 |
| 19236766 | 2009 | [Effect of human cytomegalovirus infection on the expression of hoxc4 and hoxc6 genes in the proliferation of lymphocytic progenitor cells]. | 1 |
| 19363484 | 2009 | HoxC4 binds to the promoter of the cytidine deaminase AID gene to induce AID expression, class-switch DNA recombination and somatic hypermutation. | 82 |
| 19236766 | 2009 | [Effect of human cytomegalovirus infection on the expression of hoxc4 and hoxc6 genes in the proliferation of lymphocytic progenitor cells]. | 1 |
| 19363484 | 2009 | HoxC4 binds to the promoter of the cytidine deaminase AID gene to induce AID expression, class-switch DNA recombination and somatic hypermutation. | 82 |
| 15674412 | 2005 | A new recurrent inversion, inv(7)(p15q34), leads to transcriptional activation of HOXA10 and HOXA11 in a subset of T-cell acute lymphoblastic leukemias. | 28 |
Citation
Dessen P
HOXC4 (homeobox C4)
Atlas Genet Cytogenet Oncol Haematol. 2014-08-01
Online version: http://atlasgeneticsoncology.org/gene/54368/hoxc4-(homeobox-c4)
