HTR1E (5-hydroxytryptamine receptor 1E)

2014-08-01  

Identity

HGNC
LOCATION
6q14.3
LOCUSID
ALIAS
5-HT1E
FUSION GENES

Other Information

Locus ID:

NCBI: 3354
MIM: 182132
HGNC: 5291
Ensembl: ENSG00000168830

Variants:

dbSNP: 3354
ClinVar: 3354
TCGA: ENSG00000168830
COSMIC: HTR1E

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000168830ENST00000305344P28566

Expression (GTEx)

0
1
2
3
4
5
6

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Taste transductionKEGGko04742
Neuroactive ligand-receptor interactionKEGGhsa04080
Taste transductionKEGGhsa04742
Serotonergic synapseKEGGhsa04726
cAMP signaling pathwayKEGGhsa04024
cAMP signaling pathwayKEGGko04024
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Amine ligand-binding receptorsREACTOMER-HSA-375280
Serotonin receptorsREACTOMER-HSA-390666
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA172GNAI1GenePathwayassociated19741567
PA173GNAI3GenePathwayassociated19741567
PA24347GNAI2GenePathwayassociated19741567

References

Pubmed IDYearTitleCitations
188215652008Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations.133
189378422008The influence of serotonin- and other genes on impulsive behavioral aggression and cognitive impulsivity in children with attention-deficit/hyperactivity disorder (ADHD): Findings from a family-based association test (FBAT) analysis.63
191561682009Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.46
190860532009Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.34
180790672008Genetic evaluation of the serotonergic system in chronic fatigue syndrome.23
190587892009A common variant in DRD3 receptor is associated with autism spectrum disorder.19
194556002010Association study of the serotoninergic system in migraine in the Spanish population.11
126274642003Suicide and serotonin: study of variation at seven serotonin receptor genes in suicide completers.9

Citation

Dessen P

HTR1E (5-hydroxytryptamine receptor 1E)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54370/htr1e-(5-hydroxytryptamine-receptor-1e)