IMMT (inner membrane mitochondrial protein)

2014-08-01  

Identity

HGNC
IMMT
LOCATION
2p11.2
LOCUSID
10989
ALIAS
HMP,MICOS60,MINOS2,Mic60,P87,P87/89,P89,PIG4,PIG52
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10989
MIM: 600378
HGNC: 6047
Ensembl: ENSG00000132305

Variants:

dbSNP: 10989
ClinVar: 10989
TCGA: ENSG00000132305
COSMIC: IMMT

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000132305ENST00000254636C9J406
ENSG00000132305ENST00000409051B9A067
ENSG00000132305ENST00000409258D6RAW4
ENSG00000132305ENST00000410111Q16891
ENSG00000132305ENST00000419070H7C463
ENSG00000132305ENST00000442664Q16891
ENSG00000132305ENST00000449247Q16891
ENSG00000132305ENST00000620815A0A087WYS0

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
388347152024Suppressing mitochondrial inner membrane protein (IMMT) inhibits the proliferation of breast cancer cells through mitochondrial remodeling and metabolic regulation.0
388347152024Suppressing mitochondrial inner membrane protein (IMMT) inhibits the proliferation of breast cancer cells through mitochondrial remodeling and metabolic regulation.0
348422802022Mitochondrial developmental encephalopathy with bilateral optic neuropathy related to homozygous variants in IMMT gene.4
348422802022Mitochondrial developmental encephalopathy with bilateral optic neuropathy related to homozygous variants in IMMT gene.4
342710052021Conserved GxxxG and WN motifs of MIC13 are essential for bridging two MICOS subcomplexes.3
342710052021Conserved GxxxG and WN motifs of MIC13 are essential for bridging two MICOS subcomplexes.3
323692332020CHCHD10-regulated OPA1-mitofilin complex mediates TDP-43-induced mitochondrial phenotypes associated with frontotemporal dementia.15
327883602020Multicolor 3D MINFLUX nanoscopy of mitochondrial MICOS proteins.35
323692332020CHCHD10-regulated OPA1-mitofilin complex mediates TDP-43-induced mitochondrial phenotypes associated with frontotemporal dementia.15
327883602020Multicolor 3D MINFLUX nanoscopy of mitochondrial MICOS proteins.35
315054352019Pediatric ependymoma: GNAO1, ASAH1, IMMT and IPO7 protein expression and 5-year prognosis correlation.2
315838412019Prognostic significance of IMMT expression in surgically-resected lung adenocarcinoma.4
315054352019Pediatric ependymoma: GNAO1, ASAH1, IMMT and IPO7 protein expression and 5-year prognosis correlation.2
315838412019Prognostic significance of IMMT expression in surgically-resected lung adenocarcinoma.4
289247452018Hypertonia-linked protein Trak1 functions with mitofusins to promote mitochondrial tethering and fusion.21

Citation

Dessen P

IMMT (inner membrane mitochondrial protein)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54377/immt-(inner-membrane-mitochondrial-protein)