JOSD1 (Josephin domain containing 1)

2014-08-01  

Identity

HGNC
LOCATION
22q13.1
LOCUSID
ALIAS
dJ508I15.2
FUSION GENES

Other Information

Locus ID:

NCBI: 9929
MIM: 615323
HGNC: 28953
Ensembl: ENSG00000100221

Variants:

dbSNP: 9929
ClinVar: 9929
TCGA: ENSG00000100221
COSMIC: JOSD1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100221ENST00000216039Q15040
ENSG00000100221ENST00000216039A0A024R1P5
ENSG00000100221ENST00000412832B0QY57
ENSG00000100221ENST00000417712B0QY55
ENSG00000100221ENST00000427389B0QY56
ENSG00000100221ENST00000456626B0QY58
ENSG00000100221ENST00000545590H0YGT9

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
DeubiquitinationREACTOMER-HSA-5688426
Josephin domain DUBsREACTOMER-HSA-5689877

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
310437002020JOSD1 inhibits mitochondrial apoptotic signalling to drive acquired chemoresistance in gynaecological cancer by stabilizing MCL1.31
310437002020JOSD1 inhibits mitochondrial apoptotic signalling to drive acquired chemoresistance in gynaecological cancer by stabilizing MCL1.31
283551052017JOSD1 Negatively Regulates Type-I Interferon Antiviral Activity by Deubiquitinating and Stabilizing SOCS1.16
283551052017JOSD1 Negatively Regulates Type-I Interferon Antiviral Activity by Deubiquitinating and Stabilizing SOCS1.16
185797252008Identification of NR5A1 (SF-1/AD4BP) gene expression modulators by large-scale gain and loss of function studies.4
185797252008Identification of NR5A1 (SF-1/AD4BP) gene expression modulators by large-scale gain and loss of function studies.4

Citation

Dessen P

JOSD1 (Josephin domain containing 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54389/josd1-(josephin-domain-containing-1)