Identity
HGNC
LOCATION
19p13.11
LOCUSID
ALIAS
KCa2.1,SK1,SKCA1,hSK1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 3780
MIM: 602982
HGNC: 6290
Ensembl: ENSG00000105642
Variants:
dbSNP: 3780
ClinVar: 3780
TCGA: ENSG00000105642
COSMIC: KCNN1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000105642 | ENST00000222249 | Q92952 |
| ENSG00000105642 | ENST00000609922 | V9GYV2 |
| ENSG00000105642 | ENST00000615435 | A0A087X2E7 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Insulin secretion | KEGG | hsa04911 |
| Neuronal System | REACTOME | R-HSA-112316 |
| Potassium Channels | REACTOME | R-HSA-1296071 |
| Ca2+ activated K+ channels | REACTOME | R-HSA-1296052 |
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA10832 | corticosteroids | Chemical | VariantAnnotation | associated | PD | 30697902 | |
| PA443450 | Asthma | Disease | VariantAnnotation | associated | PD | 30697902 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38018635 | 2024 | A single coiled-coil domain mutation in hIKCa channel subunits disrupts preferential formation of heteromeric hSK1:hIKCa channels. | 1 |
| 38018635 | 2024 | A single coiled-coil domain mutation in hIKCa channel subunits disrupts preferential formation of heteromeric hSK1:hIKCa channels. | 1 |
| 37831636 | 2023 | KCNN1 promotes proliferation and metastasis of breast cancer via ERLIN2-mediated stabilization and K63-dependent ubiquitination of Cyclin B1. | 0 |
| 37831636 | 2023 | KCNN1 promotes proliferation and metastasis of breast cancer via ERLIN2-mediated stabilization and K63-dependent ubiquitination of Cyclin B1. | 0 |
| 34043300 | 2021 | Targeting K(ca)3.1 Channels in Cancer. | 5 |
| 34111326 | 2021 | Differential regulation of K(Ca) 2.1 (KCNN1) K(+) channel expression by histone deacetylases in atrial fibrillation with concomitant heart failure. | 8 |
| 34043300 | 2021 | Targeting K(ca)3.1 Channels in Cancer. | 5 |
| 34111326 | 2021 | Differential regulation of K(Ca) 2.1 (KCNN1) K(+) channel expression by histone deacetylases in atrial fibrillation with concomitant heart failure. | 8 |
| 31048549 | 2019 | Preferred Formation of Heteromeric Channels between Coexpressed SK1 and IKCa Channel Subunits Provides a Unique Pharmacological Profile of Ca(2+)-Activated Potassium Channels. | 9 |
| 31048549 | 2019 | Preferred Formation of Heteromeric Channels between Coexpressed SK1 and IKCa Channel Subunits Provides a Unique Pharmacological Profile of Ca(2+)-Activated Potassium Channels. | 9 |
| 29737974 | 2018 | Ca2+/Calmodulin-Dependent Protein Kinase II (CaMKII) Increases Small-Conductance Ca2+-Activated K+ Current in Patients with Chronic Atrial Fibrillation. | 11 |
| 29737974 | 2018 | Ca2+/Calmodulin-Dependent Protein Kinase II (CaMKII) Increases Small-Conductance Ca2+-Activated K+ Current in Patients with Chronic Atrial Fibrillation. | 11 |
| 24434522 | 2014 | Subcellular expression and neuroprotective effects of SK channels in human dopaminergic neurons. | 29 |
| 24434522 | 2014 | Subcellular expression and neuroprotective effects of SK channels in human dopaminergic neurons. | 29 |
| 22154908 | 2012 | Decreased expression of small-conductance Ca2+-activated K+ channels SK1 and SK2 in human chronic atrial fibrillation. | 40 |
Citation
Dessen P
KCNN1 (potassium calcium-activated channel subfamily N member 1)
Atlas Genet Cytogenet Oncol Haematol. 2014-08-01
Online version: http://atlasgeneticsoncology.org/gene/54397/kcnn1-(potassium-calcium-activated-channel-subfamily-n-member-1)
