KDM1B (lysine demethylase 1B)

2014-08-01  

Identity

HGNC
KDM1B
LOCATION
6p22.3
LOCUSID
221656
ALIAS
AOF1,C6orf193,LSD2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 221656
MIM: 613081
HGNC: 21577
Ensembl: ENSG00000165097

Variants:

dbSNP: 221656
ClinVar: 221656
TCGA: ENSG00000165097
COSMIC: KDM1B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000165097ENST00000297792Q8NB78
ENSG00000165097ENST00000449850H0Y6H0
ENSG00000165097ENST00000546309Q08EI0
ENSG00000165097ENST00000650836Q8NB78

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
HDMs demethylate histonesREACTOMER-HSA-3214842
DeubiquitinationREACTOMER-HSA-5688426
UCH proteinasesREACTOMER-HSA-5689603

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
372277232023CircKDM1B promotes hepatocellular carcinoma progression through regulating miR-1322/PRC1 axis.0
372277232023CircKDM1B promotes hepatocellular carcinoma progression through regulating miR-1322/PRC1 axis.0
353276542022The Role of LSD1 and LSD2 in Cancers of the Gastrointestinal System: An Update.8
360754482022Lysine demethylase 1B (Kdm1b) enhances somatic reprogramming through inducing pluripotent gene expression and promoting cell proliferation.1
353276542022The Role of LSD1 and LSD2 in Cancers of the Gastrointestinal System: An Update.8
360754482022Lysine demethylase 1B (Kdm1b) enhances somatic reprogramming through inducing pluripotent gene expression and promoting cell proliferation.1
343292932021Histone demethylase AMX-1 is necessary for proper sensitivity to interstrand crosslink DNA damage.4
343292932021Histone demethylase AMX-1 is necessary for proper sensitivity to interstrand crosslink DNA damage.4
320976942020Expression profile of H3K4 demethylases with their clinical and pathological correlation in patients with clear cell renal cell carcinoma.6
327548632020In vitro evidence of NLRP3 inflammasome regulation by histone demethylase LSD2 in renal cancer: a pilot study.6
330679562020[Expression and Clinical Significance of MiR-215 and KDM1B in Patients with Diffuse Large B Cell Lymphoma].1
320976942020Expression profile of H3K4 demethylases with their clinical and pathological correlation in patients with clear cell renal cell carcinoma.6
327548632020In vitro evidence of NLRP3 inflammasome regulation by histone demethylase LSD2 in renal cancer: a pilot study.6
330679562020[Expression and Clinical Significance of MiR-215 and KDM1B in Patients with Diffuse Large B Cell Lymphoma].1
308464142019Knockdown of KDM1B inhibits cell proliferation and induces apoptosis of pancreatic cancer cells.10

Citation

Dessen P

KDM1B (lysine demethylase 1B)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54403/kdm1b-(lysine-demethylase-1b)