KLC3 (kinesin light chain 3)

2014-08-01 Affiliation

Identity

HGNC

KLC3

LOCATION

19q13.32

LOCUSID

147700

ALIAS

KLC2,KLC2L,KLCt,KNS2B

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 147700
MIM: 601334
HGNC: 20717
Ensembl: ENSG00000104892

Variants:

dbSNP: 147700
ClinVar: 147700
TCGA: ENSG00000104892
COSMIC: KLC3

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000104892	ENST00000391946	Q6P597
ENSG00000104892	ENST00000391946	A0A024R0V3
ENSG00000104892	ENST00000470402	Q6P597
ENSG00000104892	ENST00000585434	Q6P597
ENSG00000104892	ENST00000589373	K7EL76
ENSG00000104892	ENST00000589837	K7ENJ3
ENSG00000104892	ENST00000590063	K7ELP9

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Salmonella infection	KEGG	ko05132
Salmonella infection	KEGG	hsa05132
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
MHC class II antigen presentation	REACTOME	R-HSA-2132295
Hemostasis	REACTOME	R-HSA-109582
Factors involved in megakaryocyte development and platelet production	REACTOME	R-HSA-983231
Kinesins	REACTOME	R-HSA-983189
Signal Transduction	REACTOME	R-HSA-162582
Signaling by Rho GTPases	REACTOME	R-HSA-194315
RHO GTPase Effectors	REACTOME	R-HSA-195258
RHO GTPases activate KTN1	REACTOME	R-HSA-5625970
Vesicle-mediated transport	REACTOME	R-HSA-5653656
Membrane Trafficking	REACTOME	R-HSA-199991
Intra-Golgi and retrograde Golgi-to-ER traffic	REACTOME	R-HSA-6811442
Golgi-to-ER retrograde transport	REACTOME	R-HSA-8856688
COPI-dependent Golgi-to-ER retrograde traffic	REACTOME	R-HSA-6811434

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA131285527	oxaliplatin	Chemical	ClinicalAnnotation	associated	PD	19434073, 21449681, 22026922, 22188361, 29662106
PA150595617	platinum	Chemical	ClinicalAnnotation	associated	PD	19434073, 21449681, 22026922, 22188361, 29662106
PA164713176	Platinum compounds	Chemical	ClinicalAnnotation	associated	PD	19434073, 21449681, 22026922, 22188361, 29662106
PA444101	Esophageal Neoplasms	Disease	ClinicalAnnotation	associated	PD	19434073, 21449681, 22026922, 22188361, 29662106
PA444937	Mesothelioma	Disease	ClinicalAnnotation	associated	PD
PA445204	Ovarian Neoplasms	Disease	ClinicalAnnotation	associated	PD	19434073, 21449681, 22026922, 22188361, 29662106
PA445218	Pancreatic Neoplasms	Disease	ClinicalAnnotation	associated	PD	19434073, 21449681, 22026922, 22188361, 29662106
PA445601	Osteosarcoma	Disease	ClinicalAnnotation	associated	PD	19434073, 21449681, 22026922, 22188361, 29662106
PA446108	Colorectal Neoplasms	Disease	ClinicalAnnotation	associated	PD	19434073, 21449681, 22026922, 22188361, 29662106
PA449014	cisplatin	Chemical	ClinicalAnnotation	associated	PD	19434073, 21449681, 22026922, 22188361, 29662106
PA449748	gemcitabine	Chemical	ClinicalAnnotation	associated	PD

References

Pubmed ID	Year	Title	Citations
25209998	2014	Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in transport kinesins.	70
25209998	2014	Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in transport kinesins.	70
20628086	2010	Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.	15
20628086	2010	Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.	15
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	105
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	105
15464570	2004	Rat kinesin light chain 3 associates with spermatid mitochondria.	9
15464570	2004	Rat kinesin light chain 3 associates with spermatid mitochondria.	9
12594206	2003	Association of kinesin light chain with outer dense fibers in a microtubule-independent fashion.	10
12594206	2003	Association of kinesin light chain with outer dense fibers in a microtubule-independent fashion.	10
11319135	2001	Kinesin light-chain KLC3 expression in testis is restricted to spermatids.	26
11319135	2001	Kinesin light-chain KLC3 expression in testis is restricted to spermatids.	26

Citation

Dessen P

KLC3 (kinesin light chain 3)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54414/klc3-(kinesin-light-chain-3)

Cookies