LCLAT1 (lysocardiolipin acyltransferase 1)

2014-08-01  

Identity

HGNC
LCLAT1
LOCATION
2p23.1
LOCUSID
253558
ALIAS
1AGPAT8,AGPAT8,ALCAT1,HSRG1849,LYCAT,UNQ1849
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 253558
MIM: 614241
HGNC: 26756
Ensembl: ENSG00000172954

Variants:

dbSNP: 253558
ClinVar: 253558
TCGA: ENSG00000172954
COSMIC: LCLAT1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000172954ENST00000309052Q6UWP7
ENSG00000172954ENST00000319406Q6UWP7
ENSG00000172954ENST00000379509Q6UWP7
ENSG00000172954ENST00000465200C9JMW2
ENSG00000172954ENST00000465538C9JA02
ENSG00000172954ENST00000466477C9JXY8
ENSG00000172954ENST00000476038C9K0C3
ENSG00000172954ENST00000476535C9JUV9
ENSG00000172954ENST00000478015F8WEY2
ENSG00000172954ENST00000488144C9J5S5
ENSG00000172954ENST00000497423C9J6F4

Expression (GTEx)

0
1
2
3
4
5
6
7
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Glycerolipid metabolismKEGGko00561
Glycerophospholipid metabolismKEGGko00564
Glycerolipid metabolismKEGGhsa00561
Glycerophospholipid metabolismKEGGhsa00564
Metabolic pathwaysKEGGhsa01100
Triacylglycerol biosynthesisKEGGhsa_M00089
Triacylglycerol biosynthesisKEGGM00089
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Triglyceride BiosynthesisREACTOMER-HSA-75109
Phospholipid metabolismREACTOMER-HSA-1483257
Glycerophospholipid biosynthesisREACTOMER-HSA-1483206
Synthesis of PAREACTOMER-HSA-1483166
Acyl chain remodeling of CLREACTOMER-HSA-1482798

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
382005432024ALCAT1-mediated abnormal cardiolipin remodelling promotes mitochondrial injury in podocytes in diabetic kidney disease.2
382005432024ALCAT1-mediated abnormal cardiolipin remodelling promotes mitochondrial injury in podocytes in diabetic kidney disease.2
366029572023Long non-coding RNA DNMBP-AS1 promotes prostate cancer development by regulating LCLAT1.0
366029572023Long non-coding RNA DNMBP-AS1 promotes prostate cancer development by regulating LCLAT1.0
327322852020Lysocardiolipin acyltransferase regulates NSCLC cell proliferation and migration by modulating mitochondrial dynamics.9
327322852020Lysocardiolipin acyltransferase regulates NSCLC cell proliferation and migration by modulating mitochondrial dynamics.9
287510232017Lysocardiolipin acyltransferase regulates TGF-β mediated lung fibroblast differentiation.16
287510232017Lysocardiolipin acyltransferase regulates TGF-β mediated lung fibroblast differentiation.16
247797082014The mitochondrial cardiolipin remodeling enzyme lysocardiolipin acyltransferase is a novel target in pulmonary fibrosis.29
247797082014The mitochondrial cardiolipin remodeling enzyme lysocardiolipin acyltransferase is a novel target in pulmonary fibrosis.29
190750292009The microsomal cardiolipin remodeling enzyme acyl-CoA lysocardiolipin acyltransferase is an acyltransferase of multiple anionic lysophospholipids.21
190750292009The microsomal cardiolipin remodeling enzyme acyl-CoA lysocardiolipin acyltransferase is an acyltransferase of multiple anionic lysophospholipids.21

Citation

Dessen P

LCLAT1 (lysocardiolipin acyltransferase 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54419/submit-meetings/teaching-explorer/