LRRC59 (leucine rich repeat containing 59)

2014-08-01  

Identity

HGNC
LRRC59
LOCATION
17q21.33
LOCUSID
55379
ALIAS
PRO1855,p34
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 55379
MIM: 614854
HGNC: 28817
Ensembl: ENSG00000108829

Variants:

dbSNP: 55379
ClinVar: 55379
TCGA: ENSG00000108829
COSMIC: LRRC59

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000108829ENST00000225972Q96AG4
ENSG00000108829ENST00000503118I3L2E8
ENSG00000108829ENST00000576448I3L223

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
377066252023LRRC59 serves as a novel biomarker for predicting the progression and prognosis of bladder cancer.3
377066252023LRRC59 serves as a novel biomarker for predicting the progression and prognosis of bladder cancer.3
310680712020LRRC59 modulates type I interferon signaling by restraining the SQSTM1/p62-mediated autophagic degradation of pattern recognition receptor DDX58/RIG-I.36
327883422020Quantitative Proteomics Links the LRRC59 Interactome to mRNA Translation on the ER Membrane.14
310680712020LRRC59 modulates type I interferon signaling by restraining the SQSTM1/p62-mediated autophagic degradation of pattern recognition receptor DDX58/RIG-I.36
327883422020Quantitative Proteomics Links the LRRC59 Interactome to mRNA Translation on the ER Membrane.14
306505452019Targeting of LRRC59 to the Endoplasmic Reticulum and the Inner Nuclear Membrane.12
306505452019Targeting of LRRC59 to the Endoplasmic Reticulum and the Inner Nuclear Membrane.12
258336932015Leucine-rich repeat-containing protein 59 mediates nuclear import of cancerous inhibitor of PP2A in prostate cancer cells.11
264669552015LRRC59 Regulates Trafficking of Nucleic Acid-Sensing TLRs from the Endoplasmic Reticulum via Association with UNC93B1.20
258336932015Leucine-rich repeat-containing protein 59 mediates nuclear import of cancerous inhibitor of PP2A in prostate cancer cells.11
264669552015LRRC59 Regulates Trafficking of Nucleic Acid-Sensing TLRs from the Endoplasmic Reticulum via Association with UNC93B1.20
223210632012Nuclear import of exogenous FGF1 requires the ER-protein LRRC59 and the importins Kpnα1 and Kpnβ1.35
223210632012Nuclear import of exogenous FGF1 requires the ER-protein LRRC59 and the importins Kpnα1 and Kpnβ1.35

Citation

Dessen P

LRRC59 (leucine rich repeat containing 59)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54434/lrrc59-(leucine-rich-repeat-containing-59)