MACF1 (microtubule actin crosslinking factor 1)

2014-08-01  

Identity

HGNC
MACF1
LOCATION
1p34.3
LOCUSID
23499
ALIAS
ABP620,ACF7,LIS9,Lnc-PMIF,MACF,OFC4
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23499
MIM: 608271
HGNC: 13664
Ensembl: ENSG00000127603

Variants:

dbSNP: 23499
ClinVar: 23499
TCGA: ENSG00000127603
COSMIC: MACF1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000127603ENST00000360115H0Y314
ENSG00000127603ENST00000361689Q9UPN3
ENSG00000127603ENST00000372915Q9UPN3
ENSG00000127603ENST00000372925H0Y390
ENSG00000127603ENST00000422234H0Y7I1
ENSG00000127603ENST00000442046H0Y6T5
ENSG00000127603ENST00000446276H0Y4F5
ENSG00000127603ENST00000484793B4DQX9
ENSG00000127603ENST00000494012E9PS75
ENSG00000127603ENST00000496804E9PLY0
ENSG00000127603ENST00000524432E9PLY5
ENSG00000127603ENST00000530262E9PNZ4
ENSG00000127603ENST00000530275A0A0A6YYJ5
ENSG00000127603ENST00000564288H3BPE1
ENSG00000127603ENST00000567887H3BQK9
ENSG00000127603ENST00000602421B4DQX9
ENSG00000127603ENST00000671089A0A590UJG2

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
DiseaseREACTOMER-HSA-1643685
Diseases of signal transductionREACTOMER-HSA-5663202
Oncogenic MAPK signalingREACTOMER-HSA-6802957
Signaling by BRAF and RAF fusionsREACTOMER-HSA-6802952

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
381655682024LRRC1 knockdown downregulates MACF1 to inhibit the malignant progression of acute myeloid leukemia by inactivating β-catenin/c-Myc signaling.1
383720972024Exosomal circMACF1 drives PI3K/AKT/mTOR-mediated autophagy suppression in laryngeal squamous cell carcinoma.0
381655682024LRRC1 knockdown downregulates MACF1 to inhibit the malignant progression of acute myeloid leukemia by inactivating β-catenin/c-Myc signaling.1
383720972024Exosomal circMACF1 drives PI3K/AKT/mTOR-mediated autophagy suppression in laryngeal squamous cell carcinoma.0
358572512023The role of MACF1 on acute myeloid leukemia cell proliferation is involved in Runx2-targeted PI3K/Akt signaling.0
373534792023Role of microtubule actin crosslinking factor 1 (MACF1) in bipolar disorder pathophysiology and potential in lithium therapeutic mechanism.1
377138182023CircMACF1 alleviates myocardial fibrosis after acute myocardial infarction by suppressing cardiac fibroblast activation via the miR-16-5p/SMAD7 axis.0
358572512023The role of MACF1 on acute myeloid leukemia cell proliferation is involved in Runx2-targeted PI3K/Akt signaling.0
373534792023Role of microtubule actin crosslinking factor 1 (MACF1) in bipolar disorder pathophysiology and potential in lithium therapeutic mechanism.1
377138182023CircMACF1 alleviates myocardial fibrosis after acute myocardial infarction by suppressing cardiac fibroblast activation via the miR-16-5p/SMAD7 axis.0
366728242022THADA, SDHAF4, and MACF1 Gene Polymorphisms and Placental Expression in Women with Gestational Diabetes.0
366728242022THADA, SDHAF4, and MACF1 Gene Polymorphisms and Placental Expression in Women with Gestational Diabetes.0
335115912021Lissencephaly with Brainstem Hypoplasia and Dysplasia: Think MACF1.0
335735622021Expression and Clinical Significance of Microtubule-Actin Cross-Linking Factor 1 in Serous Ovarian Cancer.1
337374922021Deubiquitylation and stabilization of Acf7 by ubiquitin carboxylterminal hydrolase 14 (USP14) is critical for NSCLC migration.2

Citation

Dessen P

MACF1 (microtubule actin crosslinking factor 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54438/macf1-(microtubule-actin-crosslinking-factor-1)