Identity
HGNC
LOCATION
12q14.1
LOCUSID
ALIAS
C12orf1,TRM8,TRMT8,YDL201w
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 4234
MIM: 604466
HGNC: 7030
Ensembl: ENSG00000037897
Variants:
dbSNP: 4234
ClinVar: 4234
TCGA: ENSG00000037897
COSMIC: METTL1
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Gene Expression | REACTOME | R-HSA-74160 |
| tRNA processing | REACTOME | R-HSA-72306 |
| tRNA modification in the nucleus and cytosol | REACTOME | R-HSA-6782315 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37694982 | 2024 | N6-methyladenosine-induced METTL1 promotes tumor proliferation via CDK4. | 1 |
| 38309318 | 2024 | METTL1 facilitates ameloblastoma invasive growth via MAPK signaling pathway. | 0 |
| 38493882 | 2024 | WDR4 promotes HCC pathogenesis through N(7)-methylguanosine by regulating and interacting with METTL1. | 1 |
| 38822363 | 2024 | METTL1-mediated tRNA m(7)G methylation and translational dysfunction restricts breast cancer tumorigenesis by fueling cell cycle blockade. | 0 |
| 38967523 | 2024 | METTL1/FOXM1 promotes lung adenocarcinoma progression and gefitinib resistance by inhibiting PTPN13 expression. | 0 |
| 37694982 | 2024 | N6-methyladenosine-induced METTL1 promotes tumor proliferation via CDK4. | 1 |
| 38309318 | 2024 | METTL1 facilitates ameloblastoma invasive growth via MAPK signaling pathway. | 0 |
| 38493882 | 2024 | WDR4 promotes HCC pathogenesis through N(7)-methylguanosine by regulating and interacting with METTL1. | 1 |
| 38822363 | 2024 | METTL1-mediated tRNA m(7)G methylation and translational dysfunction restricts breast cancer tumorigenesis by fueling cell cycle blockade. | 0 |
| 38967523 | 2024 | METTL1/FOXM1 promotes lung adenocarcinoma progression and gefitinib resistance by inhibiting PTPN13 expression. | 0 |
| 36102722 | 2023 | METTL1-Mediated m7G tRNA Modification Promotes Lenvatinib Resistance in Hepatocellular Carcinoma. | 37 |
| 36599982 | 2023 | Structures and mechanisms of tRNA methylation by METTL1-WDR4. | 23 |
| 36599985 | 2023 | Structural basis of regulated m(7)G tRNA modification by METTL1-WDR4. | 20 |
| 36733406 | 2023 | Association of RNA m(7)G Modification Gene Polymorphisms with Pediatric Glioma Risk. | 1 |
| 37185458 | 2023 | METTL1/WDR4-mediated tRNA m(7)G modification and mRNA translation control promote oncogenesis and doxorubicin resistance. | 4 |
Citation
Dessen P
METTL1 (methyltransferase 1, tRNA methylguanosine)
Atlas Genet Cytogenet Oncol Haematol. 2014-08-01
Online version: http://atlasgeneticsoncology.org/gene/54449/mettl1-(methyltransferase-1-trna-methylguanosine)
