Identity
HGNC
LOCATION
12p12.3
LOCUSID
ALIAS
GIG36,MGLAP,NTI
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 4256
MIM: 154870
HGNC: 7060
Ensembl: ENSG00000111341
Variants:
dbSNP: 4256
ClinVar: 4256
TCGA: ENSG00000111341
COSMIC: MGP
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000111341 | ENST00000228938 | P08493 |
| ENSG00000111341 | ENST00000539261 | P08493 |
| ENSG00000111341 | ENST00000539261 | A0A024RAX0 |
| ENSG00000111341 | ENST00000545199 | H0YGZ6 |
Expression (GTEx)
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA28660 | GGCX | Gene | Pathway | associated |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36977707 | 2023 | Matrix Gla Protein drives stemness and tumor initiation in ovarian cancer. | 4 |
| 37187293 | 2023 | Reduced APPL1 impairs osteogenic differentiation of mesenchymal stem cells by facilitating MGP expression to disrupt the BMP2 pathway in osteoporosis. | 1 |
| 37307958 | 2023 | Assessment of MGP gene expression in cancer and contribution to prognosis. | 1 |
| 37327028 | 2023 | lncRNA MIR31HG Regulates Proliferation and Migration by Targeting Matrix Gla Protein in Nonsyndromic Cleft Lip With or Without Cleft Palate. | 0 |
| 36977707 | 2023 | Matrix Gla Protein drives stemness and tumor initiation in ovarian cancer. | 4 |
| 37187293 | 2023 | Reduced APPL1 impairs osteogenic differentiation of mesenchymal stem cells by facilitating MGP expression to disrupt the BMP2 pathway in osteoporosis. | 1 |
| 37307958 | 2023 | Assessment of MGP gene expression in cancer and contribution to prognosis. | 1 |
| 37327028 | 2023 | lncRNA MIR31HG Regulates Proliferation and Migration by Targeting Matrix Gla Protein in Nonsyndromic Cleft Lip With or Without Cleft Palate. | 0 |
| 34809448 | 2022 | Matrix Gla Protein Levels Are Associated With Arterial Stiffness and Incident Heart Failure With Preserved Ejection Fraction. | 8 |
| 35025148 | 2022 | 1,25-(OH)2D3 participates and modulates airway remodeling by reducing MGP and TGF-β1 expression in TNF-α-induced airway smooth muscle cells. | 0 |
| 34809448 | 2022 | Matrix Gla Protein Levels Are Associated With Arterial Stiffness and Incident Heart Failure With Preserved Ejection Fraction. | 8 |
| 35025148 | 2022 | 1,25-(OH)2D3 participates and modulates airway remodeling by reducing MGP and TGF-β1 expression in TNF-α-induced airway smooth muscle cells. | 0 |
| 33359068 | 2021 | Suppression MGP inhibits tumor proliferation and reverses oxaliplatin resistance in colorectal cancer. | 12 |
| 33669806 | 2021 | Circulating Levels of Dephosphorylated-Uncarboxylated Matrix Gla Protein in Patients with Acute Coronary Syndrome. | 6 |
| 33984465 | 2021 | Characterization of dynamic changes in Matrix Gla Protein (MGP) gene expression as function of genetic risk alleles, osteoarthritis relevant stimuli, and the vitamin K inhibitor warfarin. | 6 |
Citation
Dessen P
MGP (matrix Gla protein)
Atlas Genet Cytogenet Oncol Haematol. 2014-08-01
Online version: http://atlasgeneticsoncology.org/gene/54454/
