Identity
HGNC
LOCATION
4p16.3
LOCUSID
ALIAS
CML3,NACED,NAT8-LIKE
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 339983
MIM: 610647
HGNC: 26742
Ensembl: ENSG00000185818
Variants:
dbSNP: 339983
ClinVar: 339983
TCGA: ENSG00000185818
COSMIC: NAT8L
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000185818 | ENST00000423729 | Q8N9F0 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Alanine, aspartate and glutamate metabolism | KEGG | ko00250 |
| Alanine, aspartate and glutamate metabolism | KEGG | hsa00250 |
| Metabolic pathways | KEGG | hsa01100 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36580805 | 2023 | Hindering NAT8L expression in hepatocellular carcinoma increases cytosolic aspartate delivery that fosters pentose phosphate pathway and purine biosynthesis promoting cell proliferation. | 2 |
| 36882060 | 2023 | NAT8L mRNA oxidation is linked to neurodegeneration in multiple sclerosis. | 1 |
| 36580805 | 2023 | Hindering NAT8L expression in hepatocellular carcinoma increases cytosolic aspartate delivery that fosters pentose phosphate pathway and purine biosynthesis promoting cell proliferation. | 2 |
| 36882060 | 2023 | NAT8L mRNA oxidation is linked to neurodegeneration in multiple sclerosis. | 1 |
| 31924153 | 2020 | A Single Medical Marker for Diagnosis of Methamphetamine Addiction - DNA Methylation of SHATI/NAT8L Promoter Sites from Patient Blood. | 5 |
| 32612069 | 2020 | Investigating DNA Methylation of SHATI/NAT8L Promoter Sites in Blood of Unmedicated Patients with Major Depressive Disorder. | 5 |
| 31924153 | 2020 | A Single Medical Marker for Diagnosis of Methamphetamine Addiction - DNA Methylation of SHATI/NAT8L Promoter Sites from Patient Blood. | 5 |
| 32612069 | 2020 | Investigating DNA Methylation of SHATI/NAT8L Promoter Sites in Blood of Unmedicated Patients with Major Depressive Disorder. | 5 |
| 26511490 | 2016 | Cancer-Specific Production of N-Acetylaspartate via NAT8L Overexpression in Non-Small Cell Lung Cancer and Its Potential as a Circulating Biomarker. | 22 |
| 26550943 | 2016 | Purification and characterization of aspartate N-acetyltransferase: A critical enzyme in brain metabolism. | 2 |
| 27348532 | 2016 | Decreased DNA Methylation in the Shati/Nat8l Promoter in Both Patients with Schizophrenia and a Methamphetamine-Induced Murine Model of Schizophrenia-Like Phenotype. | 6 |
| 26511490 | 2016 | Cancer-Specific Production of N-Acetylaspartate via NAT8L Overexpression in Non-Small Cell Lung Cancer and Its Potential as a Circulating Biomarker. | 22 |
| 26550943 | 2016 | Purification and characterization of aspartate N-acetyltransferase: A critical enzyme in brain metabolism. | 2 |
| 27348532 | 2016 | Decreased DNA Methylation in the Shati/Nat8l Promoter in Both Patients with Schizophrenia and a Methamphetamine-Induced Murine Model of Schizophrenia-Like Phenotype. | 6 |
| 24246274 | 2014 | Deletion of SHATI/NAT8L increases dopamine D1 receptor on the cell surface in the nucleus accumbens, accelerating methamphetamine dependence. | 8 |
Citation
Dessen P
NAT8L (N-acetyltransferase 8 like)
Atlas Genet Cytogenet Oncol Haematol. 2014-08-01
Online version: http://atlasgeneticsoncology.org/gene/54488/new-content/haematological-explorer/
