NFX1 (nuclear transcription factor, X-box binding 1)

2014-08-01 Affiliation

Identity

HGNC

NFX1

LOCATION

9p13.3

LOCUSID

4799

ALIAS

NFX2,TEG-42,Tex42

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 4799
MIM: 603255
HGNC: 7803
Ensembl: ENSG00000086102

Variants:

dbSNP: 4799
ClinVar: 4799
TCGA: ENSG00000086102
COSMIC: NFX1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000086102	ENST00000318524	Q12986
ENSG00000086102	ENST00000379540	Q12986

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
34693597	2022	High expression of NFX1-123 in HPV positive head and neck squamous cell carcinomas.	3
34693597	2022	High expression of NFX1-123 in HPV positive head and neck squamous cell carcinomas.	3
30776478	2019	NFX1-123 is highly expressed in cervical cancer and increases growth and telomerase activity in HPV 16E6 expressing cells.	12
30903928	2019	HPV type 16 E6 and NFX1-123 augment JNK signaling to mediate keratinocyte differentiation and L1 expression.	6
31059266	2019	Identification of a USP9X Substrate NFX1-123 by SILAC-Based Quantitative Proteomics.	10
31375530	2019	Imaging within single NPCs reveals NXF1's role in mRNA export on the cytoplasmic side of the pore.	18
30776478	2019	NFX1-123 is highly expressed in cervical cancer and increases growth and telomerase activity in HPV 16E6 expressing cells.	12
30903928	2019	HPV type 16 E6 and NFX1-123 augment JNK signaling to mediate keratinocyte differentiation and L1 expression.	6
31059266	2019	Identification of a USP9X Substrate NFX1-123 by SILAC-Based Quantitative Proteomics.	10
31375530	2019	Imaging within single NPCs reveals NXF1's role in mRNA export on the cytoplasmic side of the pore.	18
29117186	2017	Human papillomavirus type 16 E6 and NFX1-123 mislocalize immune signaling proteins and downregulate immune gene expression in keratinocytes.	7
29117186	2017	Human papillomavirus type 16 E6 and NFX1-123 mislocalize immune signaling proteins and downregulate immune gene expression in keratinocytes.	7
27311997	2016	Involvement of the NFX1-repressor complex in PKC-δ-induced repression of hTERT transcription.	4
27311997	2016	Involvement of the NFX1-repressor complex in PKC-δ-induced repression of hTERT transcription.	4
25723053	2015	Human papillomavirus 16E6 and NFX1-123 potentiate Notch signaling and differentiation without activating cellular arrest.	13

Citation

Dessen P

NFX1 (nuclear transcription factor, X-box binding 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54500/nfx1-(nuclear-transcription-factor-x-box-binding-1)