NTNG2 (netrin G2)

2014-08-01  

Identity

HGNC
LOCATION
9q34.13
LOCUSID
ALIAS
LHLL9381,Lmnt2,NEDBASH,NTNG1,bA479K20.1
FUSION GENES

Other Information

Locus ID:

NCBI: 84628
MIM: 618689
HGNC: 14288
Ensembl: ENSG00000196358

Variants:

dbSNP: 84628
ClinVar: 84628
TCGA: ENSG00000196358
COSMIC: NTNG2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000196358ENST00000393229Q96CW9

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Axon guidanceKEGGko04360
Cell adhesion molecules (CAMs)KEGGko04514
Axon guidanceKEGGhsa04360
Cell adhesion molecules (CAMs)KEGGhsa04514
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Post-translational modification: synthesis of GPI-anchored proteinsREACTOMER-HSA-163125

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
316922052020Netrin-G2 dysfunction causes a Rett-like phenotype with areflexia.8
316922052020Netrin-G2 dysfunction causes a Rett-like phenotype with areflexia.8
313727742019Homozygous frameshift variant in NTNG2, encoding a synaptic cell adhesion molecule, in individuals with developmental delay, hypotonia, and autistic features.4
316687032019Homozygous Missense Variants in NTNG2, Encoding a Presynaptic Netrin-G2 Adhesion Protein, Lead to a Distinct Neurodevelopmental Disorder.22
313727742019Homozygous frameshift variant in NTNG2, encoding a synaptic cell adhesion molecule, in individuals with developmental delay, hypotonia, and autistic features.4
316687032019Homozygous Missense Variants in NTNG2, Encoding a Presynaptic Netrin-G2 Adhesion Protein, Lead to a Distinct Neurodevelopmental Disorder.22
229571042012Topography of Gng2- and NetrinG2-expression suggests an insular origin of the human claustrum.21
229571042012Topography of Gng2- and NetrinG2-expression suggests an insular origin of the human claustrum.21
220414492011Crystal structure of the ligand binding domain of netrin G2.12
220414492011Crystal structure of the ligand binding domain of netrin G2.12
200294092010Association of polymorphisms in the SLIT2 axonal guidance gene with anger in suicide attempters.2
203821462010Abnormal expression of netrin-G2 in temporal lobe epilepsy neurons in humans and a rat model.10
200294092010Association of polymorphisms in the SLIT2 axonal guidance gene with anger in suicide attempters.2
203821462010Abnormal expression of netrin-G2 in temporal lobe epilepsy neurons in humans and a rat model.10
175079102008Decreased mRNA expression of netrin-G1 and netrin-G2 in the temporal lobe in schizophrenia and bipolar disorder.29

Citation

Dessen P

NTNG2 (netrin G2)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54514/ntng2-(netrin-g2)