ODF2 (outer dense fiber of sperm tails 2)

2014-08-01  

Identity

HGNC
LOCATION
9q34.11
LOCUSID
ALIAS
CT134,ODF2/1,ODF2/2,ODF84
FUSION GENES

Other Information

Locus ID:

NCBI: 4957
MIM: 602015
HGNC: 8114
Ensembl: ENSG00000136811

Variants:

dbSNP: 4957
ClinVar: 4957
TCGA: ENSG00000136811
COSMIC: ODF2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000136811ENST00000351030Q5BJF6
ENSG00000136811ENST00000372791Q5BJF6
ENSG00000136811ENST00000372791A0A024R8A4
ENSG00000136811ENST00000372807Q5BJF6
ENSG00000136811ENST00000372814Q5BJF6
ENSG00000136811ENST00000393527Q5BJF6
ENSG00000136811ENST00000393527A0A024R8A5
ENSG00000136811ENST00000393533Q5BJF6
ENSG00000136811ENST00000421776Q5T4C3
ENSG00000136811ENST00000432065Q5T4C6
ENSG00000136811ENST00000434106Q5BJF6
ENSG00000136811ENST00000444119Q5BJF6
ENSG00000136811ENST00000444119A0A024R8A5
ENSG00000136811ENST00000446274Q5T4C8
ENSG00000136811ENST00000448249Q5BJF6
ENSG00000136811ENST00000470061S4R462
ENSG00000136811ENST00000483070S4R3R9
ENSG00000136811ENST00000497812S4R411
ENSG00000136811ENST00000546203Q5BJF6
ENSG00000136811ENST00000604420Q5BJF6

Expression (GTEx)

0
50
100
150
200
250
300
350
400

Pathways

PathwaySourceExternal ID
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Cilium AssemblyREACTOMER-HSA-5617833
Anchoring of the basal body to the plasma membraneREACTOMER-HSA-5620912
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G2-G2/M phasesREACTOMER-HSA-453274
G2/M TransitionREACTOMER-HSA-69275
Regulation of PLK1 Activity at G2/M TransitionREACTOMER-HSA-2565942
Centrosome maturationREACTOMER-HSA-380287
Recruitment of mitotic centrosome proteins and complexesREACTOMER-HSA-380270
Loss of proteins required for interphase microtubule organization from the centrosomeREACTOMER-HSA-380284
Loss of Nlp from mitotic centrosomesREACTOMER-HSA-380259
AURKA Activation by TPX2REACTOMER-HSA-8854518

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
370866322023Sperm DNA fragmentation and apoptosis in the sperm of men with oligozoospermia are closely related to anti-ODF2 autoantibodies.0
370866322023Sperm DNA fragmentation and apoptosis in the sperm of men with oligozoospermia are closely related to anti-ODF2 autoantibodies.0
351193602022α-/γ-Taxilin are required for centriolar subdistal appendage assembly and microtubule organization.2
356092152022Pericentriolar matrix (PCM) integrity relies on cenexin and polo-like kinase (PLK)1.4
351193602022α-/γ-Taxilin are required for centriolar subdistal appendage assembly and microtubule organization.2
356092152022Pericentriolar matrix (PCM) integrity relies on cenexin and polo-like kinase (PLK)1.4
337847962021MicroRNA-targeting in spermatogenesis: Over-expressions of microRNA-23a/b-3p and its affected targeting of the genes ODF2 and UBQLN3 in spermatozoa of patients with oligoasthenozoospermia.11
337847962021MicroRNA-targeting in spermatogenesis: Over-expressions of microRNA-23a/b-3p and its affected targeting of the genes ODF2 and UBQLN3 in spermatozoa of patients with oligoasthenozoospermia.11
323715042020C3G localizes to the mother centriole in a cenexin-dependent manner and regulates centrosome duplication and primary cilium length.2
323715042020C3G localizes to the mother centriole in a cenexin-dependent manner and regulates centrosome duplication and primary cilium length.2
306235242019Cep128 associates with Odf2 to form the subdistal appendage of the centriole.17
306235242019Cep128 associates with Odf2 to form the subdistal appendage of the centriole.17
269488792016The Mother Centriole Appendage Protein Cenexin Modulates Lumen Formation through Spindle Orientation.17
269488792016The Mother Centriole Appendage Protein Cenexin Modulates Lumen Formation through Spindle Orientation.17
229117432012A Wnt/beta-catenin pathway antagonist Chibby binds Cenexin at the distal end of mother centrioles and functions in primary cilia formation.27

Citation

Dessen P

ODF2 (outer dense fiber of sperm tails 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54516/odf2-(outer-dense-fiber-of-sperm-tails-2)