Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 94103
MIM: 610075
HGNC: 16038
Ensembl: ENSG00000172057
Variants:
dbSNP: 94103
ClinVar: 94103
TCGA: ENSG00000172057
COSMIC: ORMDL3
RNA/Proteins
Expression (GTEx)
Pathways
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA443450 | Asthma | Disease | Literature, MultilinkAnnotation | associated | 24934276 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38417794 | 2024 | ORMDL3 regulates NLRP3 inflammasome activation by maintaining ER-mitochondria contacts in human macrophages and dictates ulcerative colitis patient outcome. | 0 |
| 38417794 | 2024 | ORMDL3 regulates NLRP3 inflammasome activation by maintaining ER-mitochondria contacts in human macrophages and dictates ulcerative colitis patient outcome. | 0 |
| 35321632 | 2023 | Increased expression of ORMDL3 in allergic asthma: a case control and in vitro study. | 0 |
| 37499392 | 2023 | Evaluation of the association between clinical parameters and ADAM33 and ORMDL3 asthma gene single-nucleotide polymorphisms with the severity of COVID-19. | 1 |
| 37877592 | 2023 | Histone acetylation regulates ORMDL3 expression-mediated NLRP3 inflammasome overexpression during RSV-allergic exacerbation mice. | 1 |
| 35321632 | 2023 | Increased expression of ORMDL3 in allergic asthma: a case control and in vitro study. | 0 |
| 37499392 | 2023 | Evaluation of the association between clinical parameters and ADAM33 and ORMDL3 asthma gene single-nucleotide polymorphisms with the severity of COVID-19. | 1 |
| 37877592 | 2023 | Histone acetylation regulates ORMDL3 expression-mediated NLRP3 inflammasome overexpression during RSV-allergic exacerbation mice. | 1 |
| 35353673 | 2022 | Asthma Susceptibility Gene ORMDL3 Promotes Autophagy in Human Bronchial Epithelium. | 3 |
| 35972600 | 2022 | Regulation of the sensitivity of hepatocarcinoma cells by ORMDL3, to sorafenib by autophagy. | 0 |
| 35353673 | 2022 | Asthma Susceptibility Gene ORMDL3 Promotes Autophagy in Human Bronchial Epithelium. | 3 |
| 35972600 | 2022 | Regulation of the sensitivity of hepatocarcinoma cells by ORMDL3, to sorafenib by autophagy. | 0 |
| 33558762 | 2021 | Structural insights into the assembly and substrate selectivity of human SPT-ORMDL3 complex. | 37 |
| 33661765 | 2021 | ORMDL3 expression in ASM regulates hypertrophy, hyperplasia via TPM1 and TPM4, and contractility. | 6 |
| 33941434 | 2021 | ORMDL3/GSDMB genotype is associated with distinct phenotypes of adult asthma. | 2 |
Citation
Dessen P
ORMDL3 (ORMDL sphingolipid biosynthesis regulator 3)
Atlas Genet Cytogenet Oncol Haematol. 2014-08-01
Online version: http://atlasgeneticsoncology.org/gene/54519/ormdl3-(ormdl-sphingolipid-biosynthesis-regulator-3)
