PARD6G (par-6 family cell polarity regulator gamma)

2014-08-01  

Identity

HGNC
LOCATION
18q23
LOCUSID
ALIAS
PAR-6G,PAR6gamma
FUSION GENES

Other Information

Locus ID:

NCBI: 84552
MIM: 608976
HGNC: 16076
Ensembl: ENSG00000178184

Variants:

dbSNP: 84552
ClinVar: 84552
TCGA: ENSG00000178184
COSMIC: PARD6G

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000178184ENST00000353265Q9BYG4
ENSG00000178184ENST00000463384K7ELH1
ENSG00000178184ENST00000470488Q9BYG4

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
Axon guidanceKEGGko04360
Tight junctionKEGGko04530
Axon guidanceKEGGhsa04360
Tight junctionKEGGhsa04530
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
Hippo signaling pathwayKEGGhsa04390
Hippo signaling pathwayKEGGko04390
Rap1 signaling pathwayKEGGhsa04015
Rap1 signaling pathwayKEGGko04015
Cell-Cell communicationREACTOMER-HSA-1500931
Cell junction organizationREACTOMER-HSA-446728
Cell-cell junction organizationREACTOMER-HSA-421270
Tight junction interactionsREACTOMER-HSA-420029

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
232647372013Par6γ is at the mother centriole and controls centrosomal protein composition through a Par6α-dependent pathway.7
260730862016Par6G suppresses cell proliferation and is targeted by loss-of-function mutations in multiple cancers.7

Citation

Dessen P

PARD6G (par-6 family cell polarity regulator gamma)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54529/pard6g-(par-6-family-cell-polarity-regulator-gamma)