PHF21A (PHD finger protein 21A)

2014-08-01  

Identity

HGNC
LOCATION
11p11.2
LOCUSID
ALIAS
BHC80,BM-006,IDDBCS,NEDMS
FUSION GENES

Other Information

Locus ID:

NCBI: 51317
MIM: 608325
HGNC: 24156
Ensembl: ENSG00000135365

Variants:

dbSNP: 51317
ClinVar: 51317
TCGA: ENSG00000135365
COSMIC: PHF21A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000135365ENST00000323180Q96BD5
ENSG00000135365ENST00000418153Q96BD5
ENSG00000135365ENST00000524497E9PLU5
ENSG00000135365ENST00000525438E9PNW9
ENSG00000135365ENST00000525676H0YCM5
ENSG00000135365ENST00000527782E9PNN4
ENSG00000135365ENST00000529734E9PQM3
ENSG00000135365ENST00000529782E9PLV4
ENSG00000135365ENST00000530587H0YEK2
ENSG00000135365ENST00000531959A0A1B0GX09
ENSG00000135365ENST00000532010A0A1D5RMU1
ENSG00000135365ENST00000532028H0YCI1
ENSG00000135365ENST00000532883E9PS51
ENSG00000135365ENST00000533757E9PR02

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
HemostasisREACTOMER-HSA-109582
Factors involved in megakaryocyte development and platelet productionREACTOMER-HSA-983231
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
HDACs deacetylate histonesREACTOMER-HSA-3214815

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
368433582023A novel de novo variant in the PHF21A causes craniofacial abnormalities, intellectual disability and skeletal manifestations.0
368433582023A novel de novo variant in the PHF21A causes craniofacial abnormalities, intellectual disability and skeletal manifestations.0
363056912022PHF21A expression as a biomarker of hepatocellular carcinoma progression and prognosis.1
363056912022PHF21A expression as a biomarker of hepatocellular carcinoma progression and prognosis.1
304876432019De novo truncating variants in PHF21A cause intellectual disability and craniofacial anomalies.8
309103472019RNA Splicing of the BHC80 Gene Contributes to Neuroendocrine Prostate Cancer Progression.13
316498092019Disruption of PHF21A causes syndromic intellectual disability with craniofacial anomalies, epilepsy, hypotonia, and neurobehavioral problems including autism.17
304876432019De novo truncating variants in PHF21A cause intellectual disability and craniofacial anomalies.8
309103472019RNA Splicing of the BHC80 Gene Contributes to Neuroendocrine Prostate Cancer Progression.13
316498092019Disruption of PHF21A causes syndromic intellectual disability with craniofacial anomalies, epilepsy, hypotonia, and neurobehavioral problems including autism.17
285717212018Transcriptome Analysis Revealed Impaired cAMP Responsiveness in PHF21A-Deficient Human Cells.4
285717212018Transcriptome Analysis Revealed Impaired cAMP Responsiveness in PHF21A-Deficient Human Cells.4
281278652017Potocki-Shaffer syndrome in a child without intellectual disability-The role of PHF21A in cognitive function.8
281278652017Potocki-Shaffer syndrome in a child without intellectual disability-The role of PHF21A in cognitive function.8
227709802012Translocations disrupting PHF21A in the Potocki-Shaffer-syndrome region are associated with intellectual disability and craniofacial anomalies.44

Citation

Dessen P

PHF21A (PHD finger protein 21A)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54533/phf21a-(phd-finger-protein-21a)