PLD4 (phospholipase D family member 4)

2014-08-01  

Identity

HGNC
PLD4
LOCATION
14q32.33
LOCUSID
122618
ALIAS
C14orf175
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 122618
MIM: 618488
HGNC: 23792
Ensembl: ENSG00000166428

Variants:

dbSNP: 122618
ClinVar: 122618
TCGA: ENSG00000166428
COSMIC: PLD4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000166428ENST00000392593Q96BZ4
ENSG00000166428ENST00000540372F5H2B5
ENSG00000166428ENST00000553861G3V472
ENSG00000166428ENST00000557573G3V3J8
ENSG00000166428ENST00000649344A0A3B3IT68

Expression (GTEx)

0
1
2
3
4
5
6
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Glycerophospholipid metabolismKEGGko00564
Ether lipid metabolismKEGGko00565
Glycerophospholipid metabolismKEGGhsa00564
Ether lipid metabolismKEGGhsa00565
Metabolic pathwaysKEGGhsa01100
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Fcgamma receptor (FCGR) dependent phagocytosisREACTOMER-HSA-2029480
Role of phospholipids in phagocytosisREACTOMER-HSA-2029485
MetabolismREACTOMER-HSA-1430728
Inositol phosphate metabolismREACTOMER-HSA-1483249
Synthesis of IP3 and IP4 in the cytosolREACTOMER-HSA-1855204
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Phospholipid metabolismREACTOMER-HSA-1483257
Glycerophospholipid biosynthesisREACTOMER-HSA-1483206
Synthesis of PGREACTOMER-HSA-1483148

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
378401482023Phospholipase D4 as a signature of toll-like receptor 7 or 9 signaling is expressed on blastic T-bet + B cells in systemic lupus erythematosus.1
378401482023Phospholipase D4 as a signature of toll-like receptor 7 or 9 signaling is expressed on blastic T-bet + B cells in systemic lupus erythematosus.1
306791542019PLD4 is a genetic determinant to systemic lupus erythematosus and involved in murine autoimmune phenotypes.21
306791542019PLD4 is a genetic determinant to systemic lupus erythematosus and involved in murine autoimmune phenotypes.21
278409992017PLD4 promotes M1 macrophages to perform antitumor effects in colon cancer cells.22
278409992017PLD4 promotes M1 macrophages to perform antitumor effects in colon cancer cells.22
231248092013PLD4 as a novel susceptibility gene for systemic sclerosis in a Japanese population.39
231248092013PLD4 as a novel susceptibility gene for systemic sclerosis in a Japanese population.39

Citation

Dessen P

PLD4 (phospholipase D family member 4)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54541/pld4-(phospholipase-d-family-member-4)