RAE1 (ribonucleic acid export 1)

2014-08-01 Affiliation

Identity

HGNC

RAE1

LOCATION

20q13.31

LOCUSID

8480

ALIAS

Gle2,MIG14,MRNP41,Mnrp41,dJ481F12.3,dJ800J21.1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 8480
MIM: 603343
HGNC: 9828
Ensembl: ENSG00000101146

Variants:

dbSNP: 8480
ClinVar: 8480
TCGA: ENSG00000101146
COSMIC: RAE1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000101146	ENST00000371242	P78406
ENSG00000101146	ENST00000395840	P78406
ENSG00000101146	ENST00000395841	P78406
ENSG00000101146	ENST00000411894	B0QZ36
ENSG00000101146	ENST00000429339	B0QZ36
ENSG00000101146	ENST00000452119	B0QZ37
ENSG00000101146	ENST00000492498	E9PPG9
ENSG00000101146	ENST00000527947	E9PQ57

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
RNA transport	KEGG	ko03013
RNA transport	KEGG	hsa03013
Influenza A	KEGG	ko05164
Influenza A	KEGG	hsa05164
Nuclear pore complex	KEGG	hsa_M00427
Nuclear pore complex	KEGG	M00427
Metabolism of proteins	REACTOME	R-HSA-392499
Post-translational protein modification	REACTOME	R-HSA-597592
SUMOylation	REACTOME	R-HSA-2990846
SUMO E3 ligases SUMOylate target proteins	REACTOME	R-HSA-3108232
SUMOylation of DNA damage response and repair proteins	REACTOME	R-HSA-3108214
Disease	REACTOME	R-HSA-1643685
Infectious disease	REACTOME	R-HSA-5663205
HIV Infection	REACTOME	R-HSA-162906
HIV Life Cycle	REACTOME	R-HSA-162587
Late Phase of HIV Life Cycle	REACTOME	R-HSA-162599
Rev-mediated nuclear export of HIV RNA	REACTOME	R-HSA-165054
Host Interactions of HIV factors	REACTOME	R-HSA-162909
Interactions of Vpr with host cellular proteins	REACTOME	R-HSA-176033
Vpr-mediated nuclear import of PICs	REACTOME	R-HSA-180910
Interactions of Rev with host cellular proteins	REACTOME	R-HSA-177243
Nuclear import of Rev protein	REACTOME	R-HSA-180746
Influenza Infection	REACTOME	R-HSA-168254
Influenza Life Cycle	REACTOME	R-HSA-168255
Transport of Ribonucleoproteins into the Host Nucleus	REACTOME	R-HSA-168271
Influenza Viral RNA Transcription and Replication	REACTOME	R-HSA-168273
Viral Messenger RNA Synthesis	REACTOME	R-HSA-168325
Export of Viral Ribonucleoproteins from Nucleus	REACTOME	R-HSA-168274
NEP/NS2 Interacts with the Cellular Export Machinery	REACTOME	R-HSA-168333
Host Interactions with Influenza Factors	REACTOME	R-HSA-168253
NS1 Mediated Effects on Host Pathways	REACTOME	R-HSA-168276
Immune System	REACTOME	R-HSA-168256
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Interferon Signaling	REACTOME	R-HSA-913531
Antiviral mechanism by IFN-stimulated genes	REACTOME	R-HSA-1169410
ISG15 antiviral mechanism	REACTOME	R-HSA-1169408
Gene Expression	REACTOME	R-HSA-74160
Processing of Capped Intron-Containing Pre-mRNA	REACTOME	R-HSA-72203
Transport of Mature Transcript to Cytoplasm	REACTOME	R-HSA-72202
Transport of Mature mRNA derived from an Intron-Containing Transcript	REACTOME	R-HSA-159236
Transport of Mature mRNAs Derived from Intronless Transcripts	REACTOME	R-HSA-159234
Transport of the SLBP Dependant Mature mRNA	REACTOME	R-HSA-159230
Transport of the SLBP independent Mature mRNA	REACTOME	R-HSA-159227
Transport of Mature mRNA Derived from an Intronless Transcript	REACTOME	R-HSA-159231
Gene Silencing by RNA	REACTOME	R-HSA-211000
Transcriptional regulation by small RNAs	REACTOME	R-HSA-5578749
Metabolism of non-coding RNA	REACTOME	R-HSA-194441
snRNP Assembly	REACTOME	R-HSA-191859
Cell Cycle	REACTOME	R-HSA-1640170
Cell Cycle, Mitotic	REACTOME	R-HSA-69278
M Phase	REACTOME	R-HSA-68886
Mitotic Prophase	REACTOME	R-HSA-68875
Nuclear Envelope Breakdown	REACTOME	R-HSA-2980766
Nuclear Pore Complex (NPC) Disassembly	REACTOME	R-HSA-3301854
Transmembrane transport of small molecules	REACTOME	R-HSA-382551
SLC-mediated transmembrane transport	REACTOME	R-HSA-425407
Hexose transport	REACTOME	R-HSA-189200
Glucose transport	REACTOME	R-HSA-70153
Regulation of Glucokinase by Glucokinase Regulatory Protein	REACTOME	R-HSA-170822
Metabolism	REACTOME	R-HSA-1430728
Metabolism of carbohydrates	REACTOME	R-HSA-71387
Cellular responses to stress	REACTOME	R-HSA-2262752
Cellular response to heat stress	REACTOME	R-HSA-3371556
Regulation of HSF1-mediated heat shock response	REACTOME	R-HSA-3371453
tRNA processing	REACTOME	R-HSA-72306
tRNA processing in the nucleus	REACTOME	R-HSA-6784531
SUMOylation of RNA binding proteins	REACTOME	R-HSA-4570464
SUMOylation of DNA replication proteins	REACTOME	R-HSA-4615885

References

Pubmed ID	Year	Title	Citations
38507240	2024	SARS-CoV-2 Orf6 is positioned in the nuclear pore complex by Rae1 to inhibit nucleocytoplasmic transport.	0
38507240	2024	SARS-CoV-2 Orf6 is positioned in the nuclear pore complex by Rae1 to inhibit nucleocytoplasmic transport.	0
36810690	2023	Super-Enhancer-Driven RAE1 Shows Higher Protein Levels in Tumor Compared to Adjacent Nonmalignant Stroma in High-Grade Serous Ovarian Cancer Patients.	1
37511350	2023	Insights into the SARS-CoV-2 ORF6 Mechanism of Action.	2
36810690	2023	Super-Enhancer-Driven RAE1 Shows Higher Protein Levels in Tumor Compared to Adjacent Nonmalignant Stroma in High-Grade Serous Ovarian Cancer Patients.	1
37511350	2023	Insights into the SARS-CoV-2 ORF6 Mechanism of Action.	2
33279621	2021	Lysine acetylation of NKG2D ligand Rae-1 stabilizes the protein and sensitizes tumor cells to NKG2D immune surveillance.	4
33360543	2021	Overexpression of SARS-CoV-2 protein ORF6 dislocates RAE1 and NUP98 from the nuclear pore complex.	41
34008277	2021	Mitotic checkpoint regulator RAE1 promotes tumor growth in colorectal cancer.	11
33279621	2021	Lysine acetylation of NKG2D ligand Rae-1 stabilizes the protein and sensitizes tumor cells to NKG2D immune surveillance.	4
33360543	2021	Overexpression of SARS-CoV-2 protein ORF6 dislocates RAE1 and NUP98 from the nuclear pore complex.	41
34008277	2021	Mitotic checkpoint regulator RAE1 promotes tumor growth in colorectal cancer.	11
30683868	2019	RAE1 promotes BMAL1 shuttling and regulates degradation and activity of CLOCK: BMAL1 heterodimer.	10
30683868	2019	RAE1 promotes BMAL1 shuttling and regulates degradation and activity of CLOCK: BMAL1 heterodimer.	10
29293652	2018	USP11 deubiquitinates RAE1 and plays a key role in bipolar spindle formation.	15

Citation

Dessen P

RAE1 (ribonucleic acid export 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54571/rae1-(ribonucleic-acid-export-1)

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