RCOR1 (REST corepressor 1)

2014-08-01  

Identity

HGNC
RCOR1
LOCATION
14q32.31
LOCUSID
23186
ALIAS
COREST,RCOR
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23186
MIM: 607675
HGNC: 17441
Ensembl: ENSG00000089902

Variants:

dbSNP: 23186
ClinVar: 23186
TCGA: ENSG00000089902
COSMIC: RCOR1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000089902ENST00000262241Q9UKL0
ENSG00000089902ENST00000560472H0YNY4

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Huntington's diseaseKEGGko05016
Huntington's diseaseKEGGhsa05016
HemostasisREACTOMER-HSA-109582
Factors involved in megakaryocyte development and platelet productionREACTOMER-HSA-983231
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
HDACs deacetylate histonesREACTOMER-HSA-3214815

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
378784192023GSE1 links the HDAC1/CoREST co-repressor complex to DNA damage.0
378784192023GSE1 links the HDAC1/CoREST co-repressor complex to DNA damage.0
337420532021Genome-wide association study suggests that variation at the RCOR1 locus is associated with tinnitus in UK Biobank.9
337420532021Genome-wide association study suggests that variation at the RCOR1 locus is associated with tinnitus in UK Biobank.9
319176882020Inhibiting the coregulator CoREST impairs Foxp3+ Treg function and promotes antitumor immunity.30
321017462020Mechanism of Crosstalk between the LSD1 Demethylase and HDAC1 Deacetylase in the CoREST Complex.46
322513642020MYT1 attenuates neuroblastoma cell differentiation by interacting with the LSD1/CoREST complex.4
323064312020RCOR1 directly binds to MED28 and weakens its inducing effect on cancer stem cell-like activity of oral cavity squamous cell carcinoma cells.5
323968212020Crystal Structure of the LSD1/CoREST Histone Demethylase Bound to Its Nucleosome Substrate.43
319176882020Inhibiting the coregulator CoREST impairs Foxp3+ Treg function and promotes antitumor immunity.30
321017462020Mechanism of Crosstalk between the LSD1 Demethylase and HDAC1 Deacetylase in the CoREST Complex.46
322513642020MYT1 attenuates neuroblastoma cell differentiation by interacting with the LSD1/CoREST complex.4
323064312020RCOR1 directly binds to MED28 and weakens its inducing effect on cancer stem cell-like activity of oral cavity squamous cell carcinoma cells.5
323968212020Crystal Structure of the LSD1/CoREST Histone Demethylase Bound to Its Nucleosome Substrate.43
308892142019Aicardi-Goutières Syndrome associated mutations of RNase H2B impair its interaction with ZMYM3 and the CoREST histone-modifying complex.4

Citation

Dessen P

RCOR1 (REST corepressor 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54578/rcor1-(rest-corepressor-1)