RNF170 (ring finger protein 170)

2014-08-01  

Identity

HGNC
LOCATION
8p11.21
LOCUSID
ALIAS
ADSA,SNAX1
FUSION GENES

Other Information

Locus ID:

NCBI: 81790
MIM: 614649
HGNC: 25358
Ensembl: ENSG00000120925

Variants:

dbSNP: 81790
ClinVar: 81790
TCGA: ENSG00000120925
COSMIC: RNF170

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000120925ENST00000240159Q96K19
ENSG00000120925ENST00000319073Q96K19
ENSG00000120925ENST00000319104Q96K19
ENSG00000120925ENST00000524954E9PNG8
ENSG00000120925ENST00000526349Q96K19
ENSG00000120925ENST00000527424Q96K19
ENSG00000120925ENST00000531440E9PP55
ENSG00000120925ENST00000534961Q96K19

Expression (GTEx)

0
5
10
15
20
25
30

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
344696212022RNF170 mutation causes autosomal dominant sensory ataxia with variable pyramidal involvement.1
344696212022RNF170 mutation causes autosomal dominant sensory ataxia with variable pyramidal involvement.1
331659792021RNF170-Related Hereditary Spastic Paraplegia: Confirmation by a Novel Mutation.2
331659792021RNF170-Related Hereditary Spastic Paraplegia: Confirmation by a Novel Mutation.2
316363532019Bi-allelic variants in RNF170 are associated with hereditary spastic paraplegia.22
316363532019Bi-allelic variants in RNF170 are associated with hereditary spastic paraplegia.22
258828392015A Point Mutation in the Ubiquitin Ligase RNF170 That Causes Autosomal Dominant Sensory Ataxia Destabilizes the Protein and Impairs Inositol 1,4,5-Trisphosphate Receptor-mediated Ca2+ Signaling.16
258828392015A Point Mutation in the Ubiquitin Ligase RNF170 That Causes Autosomal Dominant Sensory Ataxia Destabilizes the Protein and Impairs Inositol 1,4,5-Trisphosphate Receptor-mediated Ca2+ Signaling.16
211154672011A mutation in the RNF170 gene causes autosomal dominant sensory ataxia.19
216100682011RNF170 protein, an endoplasmic reticulum membrane ubiquitin ligase, mediates inositol 1,4,5-trisphosphate receptor ubiquitination and degradation.57
211154672011A mutation in the RNF170 gene causes autosomal dominant sensory ataxia.19
216100682011RNF170 protein, an endoplasmic reticulum membrane ubiquitin ligase, mediates inositol 1,4,5-trisphosphate receptor ubiquitination and degradation.57

Citation

Dessen P

RNF170 (ring finger protein 170)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54584/rnf170-(ring-finger-protein-170)