ROBO2 (roundabout guidance receptor 2)

2014-08-01  

Identity

HGNC
ROBO2
LOCATION
3p12.3
LOCUSID
6092
ALIAS
SAX3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6092
MIM: 602431
HGNC: 10250
Ensembl: ENSG00000185008

Variants:

dbSNP: 6092
ClinVar: 6092
TCGA: ENSG00000185008
COSMIC: ROBO2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000185008ENST00000332191F8W703
ENSG00000185008ENST00000461745Q9HCK4
ENSG00000185008ENST00000471893H7C4U9
ENSG00000185008ENST00000473767F8WBR3
ENSG00000185008ENST00000475334H7C4W9
ENSG00000185008ENST00000487694Q9HCK4
ENSG00000185008ENST00000490534H7C4J7
ENSG00000185008ENST00000490991H7C4V8
ENSG00000185008ENST00000602589R4GMM8
ENSG00000185008ENST00000614793A0A087WWM5

Expression (GTEx)

0
1
2
3
4
5
6
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Axon guidanceKEGGko04360
Axon guidanceKEGGhsa04360
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Signaling by Robo receptorREACTOMER-HSA-376176
Regulation of Commissural axon pathfinding by Slit and RoboREACTOMER-HSA-428542

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
376602812024SALL4 advances the proliferation and tumor cell stemness of colon cancer cells through the transcription and regulation of ROBO2.0
386127632024Overexpression of miR-25 Downregulates the Expression of ROBO2 in Idiopathic Intellectual Disability.0
376602812024SALL4 advances the proliferation and tumor cell stemness of colon cancer cells through the transcription and regulation of ROBO2.0
386127632024Overexpression of miR-25 Downregulates the Expression of ROBO2 in Idiopathic Intellectual Disability.0
355841162022An ancient founder mutation located between ROBO1 and ROBO2 is responsible for increased microtia risk in Amerindigenous populations.3
359402262022Conformational Change of the Hairpin-like-structured Robo2 Ectodomain Allows NELL1/2 Binding.0
355841162022An ancient founder mutation located between ROBO1 and ROBO2 is responsible for increased microtia risk in Amerindigenous populations.3
359402262022Conformational Change of the Hairpin-like-structured Robo2 Ectodomain Allows NELL1/2 Binding.0
341484912021ROBO2 hampers malignant biological behavior and predicts a better prognosis in pancreatic adenocarcinoma.3
341484912021ROBO2 hampers malignant biological behavior and predicts a better prognosis in pancreatic adenocarcinoma.3
320419922020Investigation of DNA variants specific to ROBO2 Isoform 'a' in Irish vesicoureteric reflux patients reveals marked CpG island variation.1
320419922020Investigation of DNA variants specific to ROBO2 Isoform 'a' in Irish vesicoureteric reflux patients reveals marked CpG island variation.1
307005562019Robo2 contains a cryptic binding site for neural EGFL-like (NELL) protein 1/2.15
315718512019Roundabout signaling pathway involved in the pathogenesis of COPD by integrative bioinformatics analysis.14
307005562019Robo2 contains a cryptic binding site for neural EGFL-like (NELL) protein 1/2.15

Citation

Dessen P

ROBO2 (roundabout guidance receptor 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54589/robo2-(roundabout-guidance-receptor-2)