ABCG2 (ATP binding cassette subfamily G member 2 (Junior blood group))

2003-02-01  

Identity

HGNC
LOCATION
4q22.1
LOCUSID
ALIAS
ABC15,ABCP,BCRP,BCRP1,BMDP,CD338,CDw338,EST157481,GOUT1,MRX,MXR,MXR-1,MXR1,UAQTL1
FUSION GENES

Other Information

Locus ID:

NCBI: 9429
MIM: 603756
HGNC: 74
Ensembl: ENSG00000118777

Variants:

dbSNP: 9429
ClinVar: 9429
TCGA: ENSG00000118777
COSMIC: ABCG2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000118777ENST00000237612Q9UNQ0
ENSG00000118777ENST00000237612A0A024RDD4
ENSG00000118777ENST00000503830F8S0F2
ENSG00000118777ENST00000505480F8S0F2
ENSG00000118777ENST00000515655Q9UNQ0
ENSG00000118777ENST00000650821Q9UNQ0
ENSG00000118777ENST00000650821A0A024RDD4

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
ABC transportersKEGGko02010
ABC transportersKEGGhsa02010
Bile secretionKEGGko04976
Bile secretionKEGGhsa04976
Transmembrane transport of small moleculesREACTOMER-HSA-382551
Iron uptake and transportREACTOMER-HSA-917937
MetabolismREACTOMER-HSA-1430728
Abacavir transport and metabolismREACTOMER-HSA-2161522
Abacavir transmembrane transportREACTOMER-HSA-2161517
Antifolate resistanceKEGGko01523
Antifolate resistanceKEGGhsa01523

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA10204tenofovirChemicalClinicalAnnotationassociatedPK28462920
PA10804imatinibChemicalClinicalAnnotation, VariantAnnotation, VipGeneassociatedPKPD18981009, 24123600, 24322003, 30713339
PA128406956fluorouracilChemicalClinicalAnnotationassociatedPD20530282, 24018773, 24338217
PA130620651anthracyclines and related substancesChemicalVipGeneassociated24021215
PA131285527oxaliplatinChemicalClinicalAnnotationassociatedPD20530282, 24338217
PA131301952gefitinibChemicalClinicalAnnotationassociatedPD17148776, 20035425, 21332310, 25554506
PA133950441hmg coa reductase inhibitorsChemicalLiterature, MultilinkAnnotation, Pathwayassociated25084202
PA134308647rosuvastatinChemicalClinicalAnnotation, DataAnnotation, LabelAnnotation, VipGeneassociatedPKPD19474787, 16784736, 18617601, 19474787, 20130569, 20207952, 20679960, 22331829, 23930675, 25630984, 28322941
PA134865839SLCO1B1GeneDataAnnotationassociated
PA151958383Gastrointestinal Stromal TumorsDiseaseClinicalAnnotationassociatedPD30713339
PA151958596curcuminChemicalVipGeneassociated25587128
PA162372840sunitinibChemicalClinicalAnnotation, VipGeneassociatedPKPD24013576, 25344452, 26244574
PA162372878dasatinibChemicalClinicalAnnotation, VariantAnnotation, VipGeneassociatedPD24322003
PA164712948Opioid anestheticsChemicalClinicalAnnotationassociatedPD30136624
PA164713083Other general anestheticsChemicalClinicalAnnotationassociatedPD30136624
PA164713176Platinum compoundsChemicalPathwayassociated19525887
PA164760843deferasiroxChemicalClinicalAnnotationassociatedPKPD27043265, 27193993, 28346059
PA164924562elacridarChemicalVipGeneassociated
PA165110729rhodamine 123ChemicalVipGeneassociated11559526
PA165110775SN-38ChemicalPathwayassociated
PA165291492pazopanibChemicalMultilinkAnnotationassociated25504632
PA165958345nilotinibChemicalClinicalAnnotation, VariantAnnotation, VipGeneassociatedPD24322003
PA166114961dolutegravirChemicalClinicalAnnotationassociatedPK28858994
PA166131630volatile anestheticsChemicalClinicalAnnotationassociatedPD30136624
PA166154579rs4149056VariantLabelAnnotationassociated
PA166156544rs2231142VariantLabelAnnotationassociated
PA166163418rucaparibChemicalLabelAnnotationassociated
PA166163740apixabanChemicalClinicalAnnotationassociatedPK28678049, 29457840
PA166184498ezetimibe / rosuvastatinChemicalLabelAnnotationassociated
PA378NR1I2GenePathwayassociated21151855
PA443434Arthritis, RheumatoidDiseaseClinicalAnnotationassociatedPD20386493, 24394199, 27217051
PA443459Atrial FibrillationDiseaseClinicalAnnotationassociatedPK28678049, 29457840
PA443557Brain NeoplasmsDiseaseClinicalAnnotationassociatedPK27052877
PA443560Breast NeoplasmsDiseaseClinicalAnnotationassociatedPD
PA443622Carcinoma, Non-Small-Cell LungDiseaseClinicalAnnotationassociatedPD18221820
PA443658Central Nervous System InfectionsDiseaseClinicalAnnotationassociatedPK29873816
PA443937Drug ToxicityDiseaseClinicalAnnotationassociatedPD30713339
PA444065EpilepsyDiseaseClinicalAnnotationassociatedPKPD26213157, 27610747, 29791014
PA444101Esophageal NeoplasmsDiseaseVipGeneassociated
PA444318GoutDiseaseClinicalAnnotationassociatedPD26810134, 29341237, 30924126
PA444516HypercholesterolemiaDiseaseClinicalAnnotationassociatedPKPD16784736, 19474787, 20130569, 20207952, 20679960, 23930675, 25630984, 28322941
PA444818Lung NeoplasmsDiseaseClinicalAnnotationassociatedPD17148776, 20035425, 21332310, 25554506
PA445019Myocardial InfarctionDiseaseClinicalAnnotationassociatedPKPD16784736, 19474787, 20130569, 20207952, 20679960, 23930675, 25630984, 28322941
PA445062NeoplasmsDiseaseClinicalAnnotationassociatedPKPD24013576, 25344452, 26244574
PA445451PsoriasisDiseaseClinicalAnnotationassociatedPD18256692
PA445601OsteosarcomaDiseaseClinicalAnnotationassociatedPKPD25778468, 29791011
PA445742Stomach NeoplasmsDiseaseVipGeneassociated
PA446108Colorectal NeoplasmsDiseaseClinicalAnnotation, VipGeneassociatedPD20530282, 24018773, 24338217
PA446171Leukemia, Myelogenous, Chronic, BCR-ABL PositiveDiseaseClinicalAnnotationassociatedPD24123600
PA446432beta-ThalassemiaDiseaseClinicalAnnotationassociatedPKPD27043265, 27193993, 28346059
PA447230HIVDiseaseClinicalAnnotationassociatedPKPD23859571, 28462920, 28858994
PA448320allopurinolChemicalClinicalAnnotation, VariantAnnotation, VipGeneassociatedPD26810134, 29341237, 30924126
PA448500atorvastatinChemicalClinicalAnnotation, VipGeneassociatedPKPD19474787
PA448771capecitabineChemicalClinicalAnnotationassociatedPD20530282, 24338217
PA448866ceftriaxoneChemicalClinicalAnnotationassociatedPK29873816
PA449165cyclophosphamideChemicalClinicalAnnotationassociatedPD
PA449167cyclosporineChemicalVipGeneassociated
PA449212daunorubicinChemicalVipGeneassociated24021215
PA449383docetaxelChemicalPathwayassociated21151855
PA449412doxorubicinChemicalClinicalAnnotation, VipGeneassociatedPD11956086
PA449441efavirenzChemicalClinicalAnnotationassociatedPD23859571
PA449688fluvastatinChemicalClinicalAnnotation, VipGeneassociatedPK19842935
PA449748gemcitabineChemicalClinicalAnnotationassociatedPD
PA450085irinotecanChemicalClinicalAnnotationassociatedPD18221820, 24018773
PA450163lamivudineChemicalPathwayassociated
PA450164lamotrigineChemicalClinicalAnnotationassociatedPKPD26213157, 27610747, 29791014
PA450198leucovorinChemicalClinicalAnnotationassociatedPD20530282, 24018773, 24338217
PA450428methotrexateChemicalClinicalAnnotation, Pathway, VipGeneassociatedPKPD18237272, 18256692, 20386493, 21317831, 25778468, 27217051, 29791011
PA450761paclitaxelChemicalPathwayassociated21151855
PA451089pravastatinChemicalPathway, VipGeneassociated19842935
PA451363simvastatinChemicalClinicalAnnotation, Literature, MultilinkAnnotation, VipGeneassociatedPK19842935, 24598718
PA451547sulfasalazineChemicalClinicalAnnotation, MultilinkAnnotation, VipGeneassociatedPKPD18167504, 24394199, 25872459, 28322941
PA451729topotecanChemicalClinicalAnnotation, VipGeneassociatedPK27052877
PA451954zidovudineChemicalPathwayassociated22960662

References

Pubmed IDYearTitleCitations
377939942024Breast cancer resistance protein polymorphism ABCG2 c.421C>A (rs2231142) moderates the effect of valproate on lamotrigine trough concentrations in adults with epilepsy.0
380120782024Carboranes as Potent Phenyl Mimetics: A Comparative Study on the Reversal of ABCG2-Mediated Drug Resistance by Carboranylquinazolines and Their Organic Isosteres.0
381817892024ABCG2 is an itaconate exporter that limits antibacterial innate immunity by alleviating TFEB-dependent lysosomal biogenesis.2
384099182024NAT10-mediated mRNA N4-acetylcytidine modification of MDR1 and BCRP promotes breast cancer progression.1
384234812024Roles of breast cancer resistance protein and organic anion transporting polypeptide 2B1 in gastrointestinal toxicity induced by SN-38 under inflammatory conditions.0
384266042024Adipocyte‑rich microenvironment promotes chemoresistance via upregulation of peroxisome proliferator‑activated receptor gamma/ABCG2 in epithelial ovarian cancer.1
384421332024ABCG2 transporter reduces protein aggregation in cigarette smoke condensate-exposed A549 lung cancer cells.0
384510122024ABCG2 polymorphisms and susceptibility to ARV-associated hepatotoxicity.1
385420902024ABCG2 Expression as a Potential Survival Predictor in Human Gliomas.0
377939942024Breast cancer resistance protein polymorphism ABCG2 c.421C>A (rs2231142) moderates the effect of valproate on lamotrigine trough concentrations in adults with epilepsy.0
380120782024Carboranes as Potent Phenyl Mimetics: A Comparative Study on the Reversal of ABCG2-Mediated Drug Resistance by Carboranylquinazolines and Their Organic Isosteres.0
381817892024ABCG2 is an itaconate exporter that limits antibacterial innate immunity by alleviating TFEB-dependent lysosomal biogenesis.2
384099182024NAT10-mediated mRNA N4-acetylcytidine modification of MDR1 and BCRP promotes breast cancer progression.1
384234812024Roles of breast cancer resistance protein and organic anion transporting polypeptide 2B1 in gastrointestinal toxicity induced by SN-38 under inflammatory conditions.0
384266042024Adipocyte‑rich microenvironment promotes chemoresistance via upregulation of peroxisome proliferator‑activated receptor gamma/ABCG2 in epithelial ovarian cancer.1

Citation

Dessen P

ABCG2 (ATP binding cassette subfamily G member 2 (Junior blood group))

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/546/js/css/lib/hgnc