SEC22B (SEC22 homolog B, vesicle trafficking protein)

2014-08-01  

Identity

HGNC
LOCATION
1p12
LOCUSID
ALIAS
ERS-24,SEC22L1
FUSION GENES

Other Information

Locus ID:

NCBI: 9554
MIM: 604029
HGNC: 10700
Ensembl: ENSG00000265808

Variants:

dbSNP: 9554
ClinVar: 9554
TCGA: ENSG00000265808
COSMIC: SEC22B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000265808ENST00000578049O75396
ENSG00000265808ENST00000618538A0A087X1A9

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
SNARE interactions in vesicular transportKEGGko04130
SNARE interactions in vesicular transportKEGGhsa04130
PhagosomeKEGGko04145
PhagosomeKEGGhsa04145
LegionellosisKEGGko05134
LegionellosisKEGGhsa05134
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Transport to the Golgi and subsequent modificationREACTOMER-HSA-948021
ER to Golgi Anterograde TransportREACTOMER-HSA-199977
COPII (Coat Protein 2) Mediated Vesicle TransportREACTOMER-HSA-204005
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing-Cross presentationREACTOMER-HSA-1236975
ER-Phagosome pathwayREACTOMER-HSA-1236974
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Cargo concentration in the ERREACTOMER-HSA-5694530
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Golgi-to-ER retrograde transportREACTOMER-HSA-8856688
COPI-dependent Golgi-to-ER retrograde trafficREACTOMER-HSA-6811434

References

Pubmed IDYearTitleCitations
371487412023SEC22B inhibition attenuates colorectal cancer aggressiveness and autophagic flux under unfavorable environment.0
371487412023SEC22B inhibition attenuates colorectal cancer aggressiveness and autophagic flux under unfavorable environment.0
360445532022Extended-synaptotagmin 1 engages in unconventional protein secretion mediated via SEC22B(+) vesicle pathway in liver cancer.5
360445532022Extended-synaptotagmin 1 engages in unconventional protein secretion mediated via SEC22B(+) vesicle pathway in liver cancer.5
323841412020The endoplasmic reticulum protein SEC22B interacts with NBEAL2 and is required for megakaryocyte α-granule biogenesis.9
327485712020The function of SEC22B and its role in human diseases.14
323841412020The endoplasmic reticulum protein SEC22B interacts with NBEAL2 and is required for megakaryocyte α-granule biogenesis.9
327485712020The function of SEC22B and its role in human diseases.14
260824582016Identification of Biomarkers Associated With Alzheimer's Disease by Bioinformatics Analysis.10
260824582016Identification of Biomarkers Associated With Alzheimer's Disease by Bioinformatics Analysis.10
247055522014The SNARE Sec22b has a non-fusogenic function in plasma membrane expansion.63
247055522014The SNARE Sec22b has a non-fusogenic function in plasma membrane expansion.63
222645122012The Legionella pneumophila effector DrrA is sufficient to stimulate SNARE-dependent membrane fusion.54
222645122012The Legionella pneumophila effector DrrA is sufficient to stimulate SNARE-dependent membrane fusion.54

Citation

Dessen P

SEC22B (SEC22 homolog B, vesicle trafficking protein)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54607/sec22b-(sec22-homolog-b-vesicle-trafficking-protein)