SEC23A (SEC23 homolog A, COPII coat complex component)

2014-08-01  

Identity

HGNC
LOCATION
14q21.1
LOCUSID
ALIAS
CLSD,hSec23A
FUSION GENES

Other Information

Locus ID:

NCBI: 10484
MIM: 610511
HGNC: 10701
Ensembl: ENSG00000100934

Variants:

dbSNP: 10484
ClinVar: 10484
TCGA: ENSG00000100934
COSMIC: SEC23A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100934ENST00000307712Q15436
ENSG00000100934ENST00000537403Q15436
ENSG00000100934ENST00000545328F5H365
ENSG00000100934ENST00000548032G3V1W4
ENSG00000100934ENST00000553970G3V4Q2
ENSG00000100934ENST00000555017G3V2R6
ENSG00000100934ENST00000555425G3V4V1
ENSG00000100934ENST00000556092G3V3G5
ENSG00000100934ENST00000557280G3V5X8
ENSG00000100934ENST00000557437G3V5K1
ENSG00000100934ENST00000625395G3V4Q2

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141
COPII complexKEGGhsa_M00404
COPII complexKEGGM00404
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Transport to the Golgi and subsequent modificationREACTOMER-HSA-948021
ER to Golgi Anterograde TransportREACTOMER-HSA-199977
COPII (Coat Protein 2) Mediated Vesicle TransportREACTOMER-HSA-204005
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen Presentation: Folding, assembly and peptide loading of class I MHCREACTOMER-HSA-983170
MHC class II antigen presentationREACTOMER-HSA-2132295
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Regulation of cholesterol biosynthesis by SREBP (SREBF)REACTOMER-HSA-1655829
Cargo concentration in the ERREACTOMER-HSA-5694530

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
376703842023SEC23A confers ER stress resistance in gastric cancer by forming the ER stress-SEC23A-autophagy negative feedback loop.3
378285002023Novel compound heterozygous variants of the SEC23A gene in a Chinese family with cranio-lenticulo-sutural dysplasia based on data from a large cohort of congenital cataract patients.1
376703842023SEC23A confers ER stress resistance in gastric cancer by forming the ER stress-SEC23A-autophagy negative feedback loop.3
378285002023Novel compound heterozygous variants of the SEC23A gene in a Chinese family with cranio-lenticulo-sutural dysplasia based on data from a large cohort of congenital cataract patients.1
351909312022MiR-29b-3p Inhibits the Inflammation Injury in Human Umbilical Vein Endothelial Cells by Regulating SEC23A.0
351909312022MiR-29b-3p Inhibits the Inflammation Injury in Human Umbilical Vein Endothelial Cells by Regulating SEC23A.0
295365012019Transduction with BBF2H7/CREB3L2 upregulates SEC23A protein in erythroblasts and partially corrects the hypo-glycosylation phenotype associated with CDAII.4
295365012019Transduction with BBF2H7/CREB3L2 upregulates SEC23A protein in erythroblasts and partially corrects the hypo-glycosylation phenotype associated with CDAII.4
293437642018Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels.198
300651142018Functions of the COPII gene paralogs SEC23A and SEC23B are interchangeable in vivo.41
303016032018Sec23a mediates miR-200c augmented oligometastatic to polymetastatic progression.16
293437642018Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels.198
300651142018Functions of the COPII gene paralogs SEC23A and SEC23B are interchangeable in vivo.41
303016032018Sec23a mediates miR-200c augmented oligometastatic to polymetastatic progression.16
284869292017ULK1 phosphorylates Sec23A and mediates autophagy-induced inhibition of ER-to-Golgi traffic.27

Citation

Dessen P

SEC23A (SEC23 homolog A, COPII coat complex component)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54608/sec23a-(sec23-homolog-a-copii-coat-complex-component)