SLC27A4 (solute carrier family 27 member 4)

2014-08-01  

Identity

HGNC
LOCATION
9q34.11
LOCUSID
ALIAS
ACSVL4,FATP4,IPS
FUSION GENES

Other Information

Locus ID:

NCBI: 10999
MIM: 604194
HGNC: 10998
Ensembl: ENSG00000167114

Variants:

dbSNP: 10999
ClinVar: 10999
TCGA: ENSG00000167114
COSMIC: SLC27A4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000167114ENST00000300456Q6P1M0
ENSG00000167114ENST00000300456A0A024R8D2
ENSG00000167114ENST00000372870Q6P1M0

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
PPAR signaling pathwayKEGGko03320
PPAR signaling pathwayKEGGhsa03320
Fat digestion and absorptionKEGGko04975
Fat digestion and absorptionKEGGhsa04975
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of vitamins, nucleosides, and related moleculesREACTOMER-HSA-425397
Transport of fatty acidsREACTOMER-HSA-804914
Insulin resistanceKEGGhsa04931

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
369248512023SLC27A4-mediated selective uptake of mono-unsaturated fatty acids promotes ferroptosis defense in hepatocellular carcinoma.7
372904452023PLIN5 interacts with FATP4 at membrane contact sites to promote lipid droplet-to-mitochondria fatty acid transport.13
369248512023SLC27A4-mediated selective uptake of mono-unsaturated fatty acids promotes ferroptosis defense in hepatocellular carcinoma.7
372904452023PLIN5 interacts with FATP4 at membrane contact sites to promote lipid droplet-to-mitochondria fatty acid transport.13
315954902020Impacts of deletion and ichthyosis prematurity syndrome-associated mutations in fatty acid transport protein 4 on the function of RPE65.3
323571422020The positive feedback between ACSL4 expression and O-GlcNAcylation contributes to the growth and survival of hepatocellular carcinoma.13
325191582020Physical Activity During Pregnancy Is Associated with Increased Placental FATP4 Protein Expression.6
315954902020Impacts of deletion and ichthyosis prematurity syndrome-associated mutations in fatty acid transport protein 4 on the function of RPE65.3
323571422020The positive feedback between ACSL4 expression and O-GlcNAcylation contributes to the growth and survival of hepatocellular carcinoma.13
325191582020Physical Activity During Pregnancy Is Associated with Increased Placental FATP4 Protein Expression.6
310893962019High Membranous Expression of Fatty Acid Transport Protein 4 Is Associated with Tumorigenesis and Tumor Progression in Clear Cell Renal Cell Carcinoma.22
310893962019High Membranous Expression of Fatty Acid Transport Protein 4 Is Associated with Tumorigenesis and Tumor Progression in Clear Cell Renal Cell Carcinoma.22
297012332018Ichthyosis Prematurity Syndrome due to a Novel SLC27A4 Homozygous Mutation in an Italian Patient.4
303888702018Solute Carrier Family 27 Member 4 (SLC27A4) Enhances Cell Growth, Migration, and Invasion in Breast Cancer Cells.23
297012332018Ichthyosis Prematurity Syndrome due to a Novel SLC27A4 Homozygous Mutation in an Italian Patient.4

Citation

Dessen P

SLC27A4 (solute carrier family 27 member 4)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54633/gene-fusions/gene-explorer/