SMG5 (SMG5 nonsense mediated mRNA decay factor)

2014-08-01  

Identity

HGNC
LOCATION
1q22
LOCUSID
ALIAS
EST1B,LPTS-RP1,LPTSRP1,SMG-5
FUSION GENES

Other Information

Locus ID:

NCBI: 23381
MIM: 610962
HGNC: 24644
Ensembl: ENSG00000198952

Variants:

dbSNP: 23381
ClinVar: 23381
TCGA: ENSG00000198952
COSMIC: SMG5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198952ENST00000361813Q9UPR3

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
mRNA surveillance pathwayKEGGko03015
mRNA surveillance pathwayKEGGhsa03015
Gene ExpressionREACTOMER-HSA-74160
Nonsense-Mediated Decay (NMD)REACTOMER-HSA-927802
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)REACTOMER-HSA-975957

References

Pubmed IDYearTitleCitations
376993612024Pan-Cancer Analysis of the Prognostic and Immunological Role of SMG5: A Biomarker for Cancers.1
376993612024Pan-Cancer Analysis of the Prognostic and Immunological Role of SMG5: A Biomarker for Cancers.1
379362392023Overexpression of TMEM79 combined with SMG5 is related to prognosis, tumor immune infiltration and drug sensitivity in hepatocellular carcinoma.0
379362392023Overexpression of TMEM79 combined with SMG5 is related to prognosis, tumor immune infiltration and drug sensitivity in hepatocellular carcinoma.0
341727242021SMG5-SMG7 authorize nonsense-mediated mRNA decay by enabling SMG6 endonucleolytic activity.33
341727242021SMG5-SMG7 authorize nonsense-mediated mRNA decay by enabling SMG6 endonucleolytic activity.33
293481392018Dissecting the functions of SMG5, SMG7, and PNRC2 in nonsense-mediated mRNA decay of human cells.18
293481392018Dissecting the functions of SMG5, SMG7, and PNRC2 in nonsense-mediated mRNA decay of human cells.18
274735912016MicroRNA 433 regulates nonsense-mediated mRNA decay by targeting SMG5 mRNA.3
274735912016MicroRNA 433 regulates nonsense-mediated mRNA decay by targeting SMG5 mRNA.3
250131722014Phospho-dependent and phospho-independent interactions of the helicase UPF1 with the NMD factors SMG5-SMG7 and SMG6.63
252110802014The host nonsense-mediated mRNA decay pathway restricts Mammalian RNA virus replication.94
250131722014Phospho-dependent and phospho-independent interactions of the helicase UPF1 with the NMD factors SMG5-SMG7 and SMG6.63
252110802014The host nonsense-mediated mRNA decay pathway restricts Mammalian RNA virus replication.94
168097642006Histone deacetylase 8 safeguards the human ever-shorter telomeres 1B (hEST1B) protein from ubiquitin-mediated degradation.38

Citation

Dessen P

SMG5 (SMG5 nonsense mediated mRNA decay factor)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54645/smg5-(smg5-nonsense-mediated-mrna-decay-factor)