SPP2 (secreted phosphoprotein 2)

2014-08-01  

Identity

HGNC
SPP2
LOCATION
2q37.1
LOCUSID
6694
ALIAS
SPP-24,SPP24
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6694
MIM: 602637
HGNC: 11256
Ensembl: ENSG00000072080

Variants:

dbSNP: 6694
ClinVar: 6694
TCGA: ENSG00000072080
COSMIC: SPP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000072080ENST00000168148Q13103
ENSG00000072080ENST00000373368Q13103
ENSG00000072080ENST00000425558C9J6K0

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Response to elevated platelet cytosolic Ca2+REACTOMER-HSA-76005
Platelet degranulationREACTOMER-HSA-114608

References

Pubmed IDYearTitleCitations
368832702023Secreted phosphoprotein 24 kD (Spp24) inhibits the growth of human osteosarcoma through the BMP-2/Smad signaling pathway.0
384483712023SPP2 plays a role in the tumorigenesis of hepatocellular carcinoma: A bioinformatic based analysis.0
368832702023Secreted phosphoprotein 24 kD (Spp24) inhibits the growth of human osteosarcoma through the BMP-2/Smad signaling pathway.0
384483712023SPP2 plays a role in the tumorigenesis of hepatocellular carcinoma: A bioinformatic based analysis.0
334810522021Secreted Phosphoprotein 24 is a Biomarker of Mineral Metabolism.2
334810522021Secreted Phosphoprotein 24 is a Biomarker of Mineral Metabolism.2
318493192019Association between the expression of secreted phosphoprotein - related genes and prognosis of human cancer.22
318493192019Association between the expression of secreted phosphoprotein - related genes and prognosis of human cancer.22
277938992016Secreted Phosphoprotein 24 kD Inhibits Growth of Human Prostate Cancer Cells Stimulated by BMP-2.9
277938992016Secreted Phosphoprotein 24 kD Inhibits Growth of Human Prostate Cancer Cells Stimulated by BMP-2.9
253394132015The bone matrix protein secreted phosphoprotein 24 kD (Spp24): bone metabolism regulator and starting material for biotherapeutic materials.5
254184202015A carboxy terminal BMP/TGF-β binding site in secreted phosphoprotein 24 kD independently affects BMP-2 activity.4
255019582015Spp24 derivatives stimulate a Gi-protein coupled receptor-Erk1/2 signaling pathway and modulate gene expressions in W-20-17 cells.2
264595732015SPP2 Mutations Cause Autosomal Dominant Retinitis Pigmentosa.15
253394132015The bone matrix protein secreted phosphoprotein 24 kD (Spp24): bone metabolism regulator and starting material for biotherapeutic materials.5

Citation

Dessen P

SPP2 (secreted phosphoprotein 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54665/spp2-(secreted-phosphoprotein-2)