SRSF4 (serine and arginine rich splicing factor 4)

2014-08-01  

Identity

HGNC
SRSF4
LOCATION
1p35.3
LOCUSID
6429
ALIAS
SFRS4,SRP75
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6429
MIM: 601940
HGNC: 10786
Ensembl: ENSG00000116350

Variants:

dbSNP: 6429
ClinVar: 6429
TCGA: ENSG00000116350
COSMIC: SRSF4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000116350ENST00000373795Q08170
ENSG00000116350ENST00000466448A0A0D9SEM4
ENSG00000116350ENST00000489898A0A0D9SGD2
ENSG00000116350ENST00000605204S4R2X6

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
SpliceosomeKEGGko03040
SpliceosomeKEGGhsa03040
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
Gene ExpressionREACTOMER-HSA-74160
RNA Polymerase II TranscriptionREACTOMER-HSA-73857
RNA Polymerase II Transcription TerminationREACTOMER-HSA-73856
Cleavage of Growing Transcript in the Termination RegionREACTOMER-HSA-109688
Processing of Capped Intron-Containing Pre-mRNAREACTOMER-HSA-72203
mRNA SplicingREACTOMER-HSA-72172
mRNA Splicing - Major PathwayREACTOMER-HSA-72163
mRNA 3'-end processingREACTOMER-HSA-72187
Transport of Mature Transcript to CytoplasmREACTOMER-HSA-72202
Transport of Mature mRNA derived from an Intron-Containing TranscriptREACTOMER-HSA-159236

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
383967602024Impaired Mitochondrial Function and Marrow Failure in Patients Carrying a Variant of the SRSF4 Gene.0
383967602024Impaired Mitochondrial Function and Marrow Failure in Patients Carrying a Variant of the SRSF4 Gene.0
370145442023SRSF4 Confers Temozolomide Resistance of Glioma via Accelerating Double Strand Break Repair.0
370145442023SRSF4 Confers Temozolomide Resistance of Glioma via Accelerating Double Strand Break Repair.0
320500402020Multiple nuclear localization sequences in SRSF4 protein.1
320500402020Multiple nuclear localization sequences in SRSF4 protein.1
297897872018Physiological and Pathological Function of Serine/Arginine-Rich Splicing Factor 4 and Related Diseases.9
303769892018Binding of SRSF4 to a novel enhancer modulates splicing of exon 6 of Fas pre-mRNA.8
297897872018Physiological and Pathological Function of Serine/Arginine-Rich Splicing Factor 4 and Related Diseases.9
303769892018Binding of SRSF4 to a novel enhancer modulates splicing of exon 6 of Fas pre-mRNA.8
258844972015Role of the splicing factor SRSF4 in cisplatin-induced modifications of pre-mRNA splicing and apoptosis.27
258844972015Role of the splicing factor SRSF4 in cisplatin-induced modifications of pre-mRNA splicing and apoptosis.27
217233812011An SRp75/hnRNPG complex interacting with hnRNPE2 regulates the 5' splice site of tau exon 10, whose misregulation causes frontotemporal dementia.21
217233812011An SRp75/hnRNPG complex interacting with hnRNPE2 regulates the 5' splice site of tau exon 10, whose misregulation causes frontotemporal dementia.21
206856592010Serine- and arginine-rich proteins 55 and 75 (SRp55 and SRp75) induce production of HIV-1 vpr mRNA by inhibiting the 5'-splice site of exon 3.15

Citation

Dessen P

SRSF4 (serine and arginine rich splicing factor 4)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54670/srsf4-(serine-and-arginine-rich-splicing-factor-4)