SV2B (synaptic vesicle glycoprotein 2B)

2014-08-01  

Identity

HGNC
SV2B
LOCATION
15q26.1
LOCUSID
9899
ALIAS
HsT19680
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9899
MIM: 185861
HGNC: 16874
Ensembl: ENSG00000185518

Variants:

dbSNP: 9899
ClinVar: 9899
TCGA: ENSG00000185518
COSMIC: SV2B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000185518ENST00000330276Q7L1I2
ENSG00000185518ENST00000394232Q7L1I2
ENSG00000185518ENST00000545111Q7L1I2
ENSG00000185518ENST00000557410Q7L1I2

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
ECM-receptor interactionKEGGko04512
ECM-receptor interactionKEGGhsa04512
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
Uptake and actions of bacterial toxinsREACTOMER-HSA-5339562
Neurotoxicity of clostridium toxinsREACTOMER-HSA-168799
Toxicity of botulinum toxin type A (BoNT/A)REACTOMER-HSA-5250968
Toxicity of botulinum toxin type E (BoNT/E)REACTOMER-HSA-5250992
Toxicity of botulinum toxin type D (BoNT/D)REACTOMER-HSA-5250955
Toxicity of botulinum toxin type F (BoNT/F)REACTOMER-HSA-5250981

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil

References

Pubmed IDYearTitleCitations
335887522021Differentiation of two human neuroblastoma cell lines alters SV2 expression patterns.3
335887522021Differentiation of two human neuroblastoma cell lines alters SV2 expression patterns.3
326670332020Bioinformatics analysis of potential core genes for glioblastoma.7
326670332020Bioinformatics analysis of potential core genes for glioblastoma.7
236178382014Expression pattern of synaptic vesicle protein 2 (SV2) isoforms in patients with temporal lobe epilepsy and hippocampal sclerosis.29
236178382014Expression pattern of synaptic vesicle protein 2 (SV2) isoforms in patients with temporal lobe epilepsy and hippocampal sclerosis.29
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.15
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.15
189771202009No major role of common SV2A variation for predisposition or levetiracetam response in epilepsy.8
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.105
189771202009No major role of common SV2A variation for predisposition or levetiracetam response in epilepsy.8
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.105
183671542008Linkage disequilibrium mapping of a chromosome 15q25-26 major depression linkage region and sequencing of NTRK3.16

Citation

Dessen P

SV2B (synaptic vesicle glycoprotein 2B)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54677/sv2b-(synaptic-vesicle-glycoprotein-2b)