TBC1D15 (TBC1 domain family member 15)

2014-08-01  

Identity

HGNC
TBC1D15
LOCATION
12q21.1
LOCUSID
64786
ALIAS
RAB7-GAP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 64786
MIM: 612662
HGNC: 25694
Ensembl: ENSG00000121749

Variants:

dbSNP: 64786
ClinVar: 64786
TCGA: ENSG00000121749
COSMIC: TBC1D15

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000121749ENST00000319106Q8TC07
ENSG00000121749ENST00000462788F8WCB5
ENSG00000121749ENST00000468049F8WDJ1
ENSG00000121749ENST00000472611F8WF35
ENSG00000121749ENST00000482439F8VV61
ENSG00000121749ENST00000485960Q8TC07
ENSG00000121749ENST00000491063C9JA93
ENSG00000121749ENST00000498482F8WAX5
ENSG00000121749ENST00000550746Q8TC07

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
TBC/RABGAPsREACTOMER-HSA-8854214
Mitophagy - animalKEGGko04137
Mitophagy - animalKEGGhsa04137

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
384094482024NOTCH localizes to mitochondria through the TBC1D15-FIS1 interaction and is stabilized via blockade of E3 ligase and CDK8 recruitment to reprogram tumor-initiating cells.0
384094482024NOTCH localizes to mitochondria through the TBC1D15-FIS1 interaction and is stabilized via blockade of E3 ligase and CDK8 recruitment to reprogram tumor-initiating cells.0
377771542023A conserved, noncanonical insert in FIS1 mediates TBC1D15 and DRP1 recruitment for mitochondrial fission.3
377771542023A conserved, noncanonical insert in FIS1 mediates TBC1D15 and DRP1 recruitment for mitochondrial fission.3
316644612020Annexin A6 modulates TBC1D15/Rab7/StARD3 axis to control endosomal cholesterol export in NPC1 cells.31
319580362020IFNB/interferon-β regulates autophagy via a MIR1-TBC1D15-RAB7 pathway.9
325551532020p53 destabilizing protein skews asymmetric division and enhances NOTCH activation to direct self-renewal of TICs.20
316644612020Annexin A6 modulates TBC1D15/Rab7/StARD3 axis to control endosomal cholesterol export in NPC1 cells.31
319580362020IFNB/interferon-β regulates autophagy via a MIR1-TBC1D15-RAB7 pathway.9
325551532020p53 destabilizing protein skews asymmetric division and enhances NOTCH activation to direct self-renewal of TICs.20
303169252019TBC1D15 affects glucose uptake by regulating GLUT4 translocation.8
303169252019TBC1D15 affects glucose uptake by regulating GLUT4 translocation.8
243379442014Silencing of TBC1D15 promotes RhoA activation and membrane blebbing.7
245694792014Mitochondrial Rab GAPs govern autophagosome biogenesis during mitophagy.170
243379442014Silencing of TBC1D15 promotes RhoA activation and membrane blebbing.7

Citation

Dessen P

TBC1D15 (TBC1 domain family member 15)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54689/tbc1d15-(tbc1-domain-family-member-15)