TBCB (tubulin folding cofactor B)

2014-08-01  

Identity

HGNC
LOCATION
19q13.12
LOCUSID
ALIAS
CG22,CKAP1,CKAPI
FUSION GENES

Other Information

Locus ID:

NCBI: 1155
MIM: 601303
HGNC: 1989
Ensembl: ENSG00000105254

Variants:

dbSNP: 1155
ClinVar: 1155
TCGA: ENSG00000105254
COSMIC: TBCB

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105254ENST00000221855Q99426
ENSG00000105254ENST00000585746Q99426
ENSG00000105254ENST00000586868K7ER04
ENSG00000105254ENST00000588385K7EP07
ENSG00000105254ENST00000589624K7EQH0
ENSG00000105254ENST00000589996K7EK42
ENSG00000105254ENST00000591296K7EL99
ENSG00000105254ENST00000629269K7EQH0
ENSG00000105254ENST00000651435A0A494C0X0

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Protein foldingREACTOMER-HSA-391251
Post-chaperonin tubulin folding pathwayREACTOMER-HSA-389977

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
191655272009Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia.56
255052422015Microtubule-associated proteins 1 (MAP1) promote human immunodeficiency virus type I (HIV-1) intracytoplasmic routing to the nucleus.19
191688532009Gigaxonin controls vimentin organization through a tubulin chaperone-independent pathway.18
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
190382512009Tubulin cofactor B regulates microtubule densities during microglia transition to the reactive states.10
259088462015The structure of the complex between α-tubulin, TBCE and TBCB reveals a tubulin dimer dissociation mechanism.9
180483402007Dynamic interplay between nitration and phosphorylation of tubulin cofactor B in the control of microtubule dynamics.8
229409192013Autoinhibition of TBCB regulates EB1-mediated microtubule dynamics.4
283938582017HILI destabilizes microtubules by suppressing phosphorylation and Gigaxonin-mediated degradation of TBCB.4

Citation

Dessen P

TBCB (tubulin folding cofactor B)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54692/tbcb-(tubulin-folding-cofactor-b)