ABI3 (ABI family member 3)

2003-10-01  

Identity

HGNC
LOCATION
17q21.32
LOCUSID
ALIAS
NESH,SSH3BP3

Other Information

Locus ID:

NCBI: 51225
MIM: 606363
HGNC: 29859
Ensembl: ENSG00000108798

Variants:

dbSNP: 51225
ClinVar: 51225
TCGA: ENSG00000108798
COSMIC: ABI3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000108798ENST00000225941Q9P2A4
ENSG00000108798ENST00000419580Q9P2A4
ENSG00000108798ENST00000571035I3L1X2
ENSG00000108798ENST00000573347I3L3W4

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
287149762017Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease.181
119560712002Forced expression of NESH suppresses motility and metastatic dissemination of malignant cells.13
171011332006NESH (Abi-3) is present in the Abi/WAVE complex but does not promote c-Abl-mediated phosphorylation.13
212235852011ABI3 ectopic expression reduces in vitro and in vivo cell growth properties while inducing senescence.13
303269452018ABI3 and PLCG2 missense variants as risk factors for neurodegenerative diseases in Caucasians and African Americans.8
270360192016Transcriptional regulation of the potential tumor suppressor ABI3 gene in thyroid carcinomas: interplay between methylation and NKX2-1 availability.4
307052882019Transethnic meta-analysis of rare coding variants in PLCG2, ABI3, and TREM2 supports their general contribution to Alzheimer's disease.4

Citation

Dessen P

ABI3 (ABI family member 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-10-01

Online version: http://atlasgeneticsoncology.org/gene/547/abi3-(abi-family-member-3)