TPST2 (tyrosylprotein sulfotransferase 2)

2014-08-01  

Identity

HGNC
TPST2
LOCATION
22q12.1
LOCUSID
8459
ALIAS
TANGO13B,TPST-2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8459
MIM: 603126
HGNC: 12021
Ensembl: ENSG00000128294

Variants:

dbSNP: 8459
ClinVar: 8459
TCGA: ENSG00000128294
COSMIC: TPST2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000128294ENST00000338754O60704
ENSG00000128294ENST00000338754A0A024R1G9
ENSG00000128294ENST00000398110O60704
ENSG00000128294ENST00000398110A0A024R1G9
ENSG00000128294ENST00000403880O60704
ENSG00000128294ENST00000403880A0A024R1G9
ENSG00000128294ENST00000440953B1AHJ8
ENSG00000128294ENST00000442495B1AHJ6
ENSG00000128294ENST00000445720B1AHJ5
ENSG00000128294ENST00000450022B1AHK0
ENSG00000128294ENST00000453117B1AHJ9
ENSG00000128294ENST00000454778B1AHJ7

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
121696682002Tyrosine sulfation of CCR5 N-terminal peptide by tyrosylprotein sulfotransferases 1 and 2 follows a discrete pattern and temporal sequence.36
234813802013Crystal structure of human tyrosylprotein sulfotransferase-2 reveals the mechanism of protein tyrosine sulfation reaction.18
186723802008Mass spectrometric kinetic analysis of human tyrosylprotein sulfotransferase-1 and -2.14
193430462009Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.3
261089872015Computational Evidence for the Catalytic Mechanism of Tyrosylprotein Sulfotransferases: A Density Functional Theory Investigation.2
204609472010Sequence analysis of the human tyrosylprotein sulfotransferase-2 gene in subjects with chronic pancreatitis.1
204609472010Sequence analysis of the human tyrosylprotein sulfotransferase-2 gene in subjects with chronic pancreatitis.1
120568002002Shear stress mediates tyrosylprotein sulfotransferase isoform shift in human endothelial cells.0

Citation

Dessen P

TPST2 (tyrosylprotein sulfotransferase 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54719/tpst2-(tyrosylprotein-sulfotransferase-2)