TRIM38 (tripartite motif containing 38)

2014-08-01  

Identity

HGNC
TRIM38
LOCATION
6p22.2
LOCUSID
10475
ALIAS
RNF15,RORET
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10475
HGNC: 10059
Ensembl: ENSG00000112343

Variants:

dbSNP: 10475
ClinVar: 10475
TCGA: ENSG00000112343
COSMIC: TRIM38

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000112343ENST00000357085O00635
ENSG00000112343ENST00000357085A0A024QZY4

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Interferon gamma signalingREACTOMER-HSA-877300

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
366233522023The antiviral activity of tripartite motif protein 38 in hepatitis B virus replication and gene expression and its association with treatment responses during PEG-IFN-α antiviral therapy.2
371167112023Tripartite motif 38 alleviates the pathological process of NAFLD-NASH by promoting TAB2 degradation.1
380121392023Investigation into the role of the MITA-TRIM38 interaction in regulating pyroptosis and maintaining immune tolerance at the maternal-fetal interface.1
366233522023The antiviral activity of tripartite motif protein 38 in hepatitis B virus replication and gene expression and its association with treatment responses during PEG-IFN-α antiviral therapy.2
371167112023Tripartite motif 38 alleviates the pathological process of NAFLD-NASH by promoting TAB2 degradation.1
380121392023Investigation into the role of the MITA-TRIM38 interaction in regulating pyroptosis and maintaining immune tolerance at the maternal-fetal interface.1
349061612021TRIM38 triggers the uniquitination and degradation of glucose transporter type 1 (GLUT1) to restrict tumor progression in bladder cancer.15
349061612021TRIM38 triggers the uniquitination and degradation of glucose transporter type 1 (GLUT1) to restrict tumor progression in bladder cancer.15
282952712017NLRP6 facilitates the interaction between TAB2/3 and TRIM38 in rheumatoid arthritis fibroblast-like synoviocytes.15
282952712017NLRP6 facilitates the interaction between TAB2/3 and TRIM38 in rheumatoid arthritis fibroblast-like synoviocytes.15
230564702012TRIM38 negatively regulates TLR3-mediated IFN-β signaling by targeting TRIF for degradation.43
230564702012TRIM38 negatively regulates TLR3-mediated IFN-β signaling by targeting TRIF for degradation.43
213066522011Enterovirus 71 induces degradation of TRIM38, a potential E3 ubiquitin ligase.9
217898582011[Identification A novel protein TRIM38 that activate NF-kappaB signaling pathways].3
213066522011Enterovirus 71 induces degradation of TRIM38, a potential E3 ubiquitin ligase.9

Citation

Dessen P

TRIM38 (tripartite motif containing 38)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54723/trim38-(tripartite-motif-containing-38)