TRPC4AP (transient receptor potential cation channel subfamily C member 4 associated protein)

2014-08-01 Affiliation

Identity

HGNC

TRPC4AP

LOCATION

20q11.22

LOCUSID

26133

ALIAS

C20orf188,PPP1R158,TRRP4AP,TRUSS

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 26133
MIM: 608430
HGNC: 16181
Ensembl: ENSG00000100991

Variants:

dbSNP: 26133
ClinVar: 26133
TCGA: ENSG00000100991
COSMIC: TRPC4AP

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000100991	ENST00000252015	Q8TEL6
ENSG00000100991	ENST00000451813	Q8TEL6

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Transmembrane transport of small molecules	REACTOME	R-HSA-382551
Ion channel transport	REACTOME	R-HSA-983712
Stimuli-sensing channels	REACTOME	R-HSA-2672351
TRP channels	REACTOME	R-HSA-3295583

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
32428920	2020	Identification of Transient Receptor Potential Channel 4-Associated Protein as a Novel Candidate Gene Causing Congenital Primary Hypothyroidism.	4
32428920	2020	Identification of Transient Receptor Potential Channel 4-Associated Protein as a Novel Candidate Gene Causing Congenital Primary Hypothyroidism.	4
29704259	2018	TRUSS Exacerbates NAFLD Development by Promoting IκBα Degradation in Mice.	7
29704259	2018	TRUSS Exacerbates NAFLD Development by Promoting IκBα Degradation in Mice.	7
26038816	2015	The G1 phase E3 ubiquitin ligase TRUSS that gets deregulated in human cancers is a novel substrate of the S-phase E3 ubiquitin ligase Skp2.	13
26038816	2015	The G1 phase E3 ubiquitin ligase TRUSS that gets deregulated in human cancers is a novel substrate of the S-phase E3 ubiquitin ligase Skp2.	13
20458742	2010	TRUSS, TNF-R1, and TRPC ion channels synergistically reverse endoplasmic reticulum Ca2+ storage reduction in response to m1 muscarinic acetylcholine receptor signaling.	4
20551172	2010	Myc protein is stabilized by suppression of a novel E3 ligase complex in cancer cells.	57
20458742	2010	TRUSS, TNF-R1, and TRPC ion channels synergistically reverse endoplasmic reticulum Ca2+ storage reduction in response to m1 muscarinic acetylcholine receptor signaling.	4
20551172	2010	Myc protein is stabilized by suppression of a novel E3 ligase complex in cancer cells.	57
18449908	2009	Genome screen of late-onset Alzheimer's extended pedigrees identifies TRPC4AP by haplotype analysis.	25
18449908	2009	Genome screen of late-onset Alzheimer's extended pedigrees identifies TRPC4AP by haplotype analysis.	25
19059308	2009	The frequency of the TRPC4AP haplotype in Alzheimer's patients.	2
19059308	2009	The frequency of the TRPC4AP haplotype in Alzheimer's patients.	2
18449908	2009	Genome screen of late-onset Alzheimer's extended pedigrees identifies TRPC4AP by haplotype analysis.	25

Citation

Dessen P

TRPC4AP (transient receptor potential cation channel subfamily C member 4 associated protein)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54726/js/lib/hgnc