Identity
HGNC
LOCATION
7q22.1
LOCUSID
ALIAS
THG-1,THG1,TILZ2
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 81628
MIM: 611914
HGNC: 21696
Ensembl: ENSG00000166925
Variants:
dbSNP: 81628
ClinVar: 81628
TCGA: ENSG00000166925
COSMIC: TSC22D4
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000166925 | ENST00000300181 | Q9Y3Q8 |
| ENSG00000166925 | ENST00000393991 | Q9Y3Q8 |
| ENSG00000166925 | ENST00000423266 | H7BZ77 |
| ENSG00000166925 | ENST00000456330 | H7C0M8 |
Expression (GTEx)
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37607779 | 2023 | Promotion of squamous cell carcinoma tumorigenesis by oncogene-mediated THG-1/TSC22D4 phosphorylation. | 2 |
| 37607779 | 2023 | Promotion of squamous cell carcinoma tumorigenesis by oncogene-mediated THG-1/TSC22D4 phosphorylation. | 2 |
| 35378329 | 2022 | Hepatocyte-specific activity of TSC22D4 triggers progressive NAFLD by impairing mitochondrial function. | 3 |
| 35714570 | 2022 | TSC22D4 promotes TGFβ1-induced activation of hepatic stellate cells. | 2 |
| 35378329 | 2022 | Hepatocyte-specific activity of TSC22D4 triggers progressive NAFLD by impairing mitochondrial function. | 3 |
| 35714570 | 2022 | TSC22D4 promotes TGFβ1-induced activation of hepatic stellate cells. | 2 |
| 31806366 | 2020 | Promotion of cellular senescence by THG-1/TSC22D4 knockout through activation of JUNB. | 3 |
| 31864704 | 2020 | THG-1 suppresses SALL4 degradation to induce stemness genes and tumorsphere formation through antagonizing NRBP1 in squamous cell carcinoma cells. | 3 |
| 31806366 | 2020 | Promotion of cellular senescence by THG-1/TSC22D4 knockout through activation of JUNB. | 3 |
| 31864704 | 2020 | THG-1 suppresses SALL4 degradation to induce stemness genes and tumorsphere formation through antagonizing NRBP1 in squamous cell carcinoma cells. | 3 |
| 27827363 | 2016 | Control of diabetic hyperglycaemia and insulin resistance through TSC22D4. | 13 |
| 27827363 | 2016 | Control of diabetic hyperglycaemia and insulin resistance through TSC22D4. | 13 |
| 20149264 | 2010 | Madm (Mlf1 adapter molecule) cooperates with Bunched A to promote growth in Drosophila. | 11 |
| 21059936 | 2010 | tRNA(His) guanylyltransferase (THG1), a unique 3'-5' nucleotidyl transferase, shares unexpected structural homology with canonical 5'-3' DNA polymerases. | 38 |
| 20149264 | 2010 | Madm (Mlf1 adapter molecule) cooperates with Bunched A to promote growth in Drosophila. | 11 |
Citation
Dessen P
TSC22D4 (TSC22 domain family member 4)
Atlas Genet Cytogenet Oncol Haematol. 2014-08-01
Online version: http://atlasgeneticsoncology.org/gene/54727/tsc22d4-(tsc22-domain-family-member-4)
